Design, synthesis and immunological evaluation of 1,2,3-triazole-tethered carbohydrate-Pam3Cys conjugates as TLR2 agonists.

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作者： Naresh,Nalla ^[1] ; Preethi,Pallavi ^[1] ; Bonam Srinivasa,Reddy ^[1] ; Sreekanth,Miryala ^[1] ; V,Naveen Kumar ^[1] ; Mohammed,Mahboob ^[2] ; M Sampath Kumar,Halmuthur ^[3]

作者单位： Vaccine Immunology Laboratory, Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. ^[1] Toxicology Laboratory, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. ^[2] Vaccine Immunology Laboratory, Natural Products Chemistry Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500007, India. Electronic address: sampath@iict.res.in. ^[3]

关键词 Adjuvants Carbohydrate Click chemistry Cytokines Pam(3)Cys

主题词药物设计(Drug Design);脂蛋白类(Lipoproteins);肽类(Peptides);Toll样受体2(Toll-Like Receptor 2);三唑类(Triazoles)

DOI 10.1016/j.bmc.2015.06.070

PMID 26234903

发布时间 2015-08-31

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