Epigenetics and therapeutic targets mediating neuroprotection.

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作者： Irfan A,Qureshi ^[1] ; Mark F,Mehler ^[2]

作者单位： Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: irfan@jhu.edu. ^[1] Roslyn and Leslie Goldstein Laboratory for Stem Cell Biology and Regenerative Medicine, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Brain Disorders and Neural Regeneration, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neurology, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Neuroscience, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Department of Psychiatry and Behavioral Sciences, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Rose F. Kennedy Center for Research on Intellectual and Developmental Disabilities, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Einstein Cancer Center, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Ruth L. and David S. Gottesman Stem Cell Institute, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Center for Epigenomics, Albert Einstein College of Medicine, Bronx, NY 10461, USA; Institute for Aging Research, Albert Einstein College of Medicine, Bronx, NY 10461, USA. Electronic address: mark.mehler@einstein.yu.edu. ^[2]

关键词 Chromatin remodeling DNA methylation Heat shock factor-1 Neurodegeneration Post-transcriptional Preconditioning RE-1 silencing transcription factor Sirtuins Stress responses

主题词后成说, 遗传(Epigenesis, Genetic);表观基因组学(Epigenomics);人类(Humans);神经系统疾病(Nervous System Diseases)

DOI 10.1016/j.brainres.2015.07.034

PMID 26236020

发布时间 2018-11-13

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