作者:
Kathryn L,Lunetta [1]
;
Felix R,Day [2]
;
Patrick,Sulem [3]
;
Katherine S,Ruth [4]
;
Joyce Y,Tung [5]
;
David A,Hinds [5]
;
Tõnu,Esko [6]
;
Cathy E,Elks [2]
;
Elisabeth,Altmaier [7]
;
Chunyan,He [8]
;
Jennifer E,Huffman [9]
;
Evelin,Mihailov [10]
;
Eleonora,Porcu [11]
;
Antonietta,Robino [12]
;
Lynda M,Rose [13]
;
Ursula M,Schick [14]
;
Lisette,Stolk [15]
;
Alexander,Teumer [16]
;
Deborah J,Thompson [17]
;
Michela,Traglia [18]
;
Carol A,Wang [19]
;
Laura M,Yerges-Armstrong [20]
;
Antonis C,Antoniou [17]
;
Caterina,Barbieri [18]
;
Andrea D,Coviello [21]
;
Francesco,Cucca [22]
;
Ellen W,Demerath [23]
;
Alison M,Dunning [24]
;
Ilaria,Gandin [25]
;
Megan L,Grove [26]
;
Daniel F,Gudbjartsson [27]
;
Lynne J,Hocking [28]
;
Albert,Hofman [29]
;
Jinyan,Huang [30]
;
Rebecca D,Jackson [31]
;
David,Karasik [32]
;
Jennifer,Kriebel [33]
;
Ethan M,Lange [34]
;
Leslie A,Lange [35]
;
Claudia,Langenberg [2]
;
Xin,Li [36]
;
Jian'an,Luan [2]
;
Reedik,Mägi [10]
;
Alanna C,Morrison [26]
;
Sandosh,Padmanabhan [37]
;
Ailith,Pirie [17]
;
Ozren,Polasek [38]
;
David,Porteous [39]
;
Alex P,Reiner [14]
;
Fernando,Rivadeneira [40]
;
Igor,Rudan [41]
;
Cinzia F,Sala [18]
;
David,Schlessinger [42]
;
Robert A,Scott [2]
;
Doris,Stöckl [43]
;
Jenny A,Visser [15]
;
Uwe,Völker [44]
;
Diego,Vozzi [12]
;
James G,Wilson [45]
;
Marek,Zygmunt [46]
;
EPIC-InterAct Consortium [26]
;
Generation Scotland [47]
;
Eric,Boerwinkle [48]
;
Julie E,Buring [49]
;
Laura,Crisponi [9]
;
Douglas F,Easton [50]
;
Caroline,Hayward [51]
;
Frank B,Hu [52]
;
Simin,Liu [19]
;
Andres,Metspalu [47]
;
Craig E,Pennell [53]
;
Paul M,Ridker [20]
;
Konstantin,Strauch [18]
;
Elizabeth A,Streeten [40]
;
Daniela,Toniolo [12]
;
André G,Uitterlinden [16]
;
Sheila,Ulivi [2]
;
Henry,Völzke [54]
;
Nicholas J,Wareham [55]
;
Melissa,Wellons [47]
;
Nora,Franceschini [56]
;
Daniel I,Chasman [4]
;
Unnur,Thorsteinsdottir [56]
;
Anna,Murray [57]
;
Kari,Stefansson [58]
;
Joanne M,Murabito [2]
;
Ken K,Ong ;
John R B,Perry
作者单位:
1] Boston University School of Public Health, Department of Biostatistics, Boston, Massachusetts 02118, USA [2] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA.
[1]
MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK.
[2]
deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland.
[3]
Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK.
[4]
23andMe Inc., 1390 Shorebird Way, Mountain View, California 94043, USA.
[5]
1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA [3] Department of Genetics, Harvard Medical School, Boston, MA 02115, USA [4] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140, Cambridge, MA 02142, USA.
[6]
1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany.
[7]
1] Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA [2] Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA.
[8]
Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
[9]
Estonian Genome Center, University of Tartu, Tartu 51010, Estonia.
[10]
1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy [3] Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA.
[11]
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste 34137, Italy.
[12]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215.
[13]
Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA.
[14]
Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands.
[15]
Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
[16]
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK.
[17]
Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy.
[18]
School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia.
[19]
Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition-University of Maryland School of Medicine, Baltimore, MD 21201, USA.
[20]
Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA, USA.
[21]
1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy.
[22]
Division of Epidemiology &Community Health, University of Minnesotta, Minneapolis, MN 55455, USA.
[23]
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
[24]
1] Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste 34137, Italy [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste 34149, Italy.
[25]
Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
[26]
1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] School of Engineering and Natural Sciences, University of Iceland, Reykjavik IS-101, Iceland.
[27]
Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK.
[28]
Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands.
[29]
State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China.
[30]
Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA.
[31]
1] Hebrew SeniorLife Institute for Aging Research, Boston, MA 02131, USA [2] Harvard Medical School, Boston, MA 02115, USA.
[32]
1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] German Center for Diabetes Research, Neuherberg 85764, Germany.
[33]
1] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA [2] Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA.
[34]
Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA.
[35]
Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA.
[36]
British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK.
[37]
Faculty of Medicine, University of Split, Split, Croatia.
[38]
Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
[39]
1] Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands [2] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands.
[40]
Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland.
[41]
National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA.
[42]
Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany.
[43]
Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany.
[44]
Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA.
[45]
Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald 17475, Germany.
[46]
1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 [2] Harvard Medical School, Boston, MA 02115, USA.
[47]
Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy.
[48]
1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK.
[49]
1] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [3] Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA.
[50]
Departments of Epidemiology and Medicine Brown University, Brown University, Providence, RI 02912, USA.
[51]
1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia.
[52]
1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich 81377, Germany.
[53]
Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA.
[54]
Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA.
[55]
1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland.
[56]
1] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA [2] Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA.
[57]
1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK [2] Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK.
[58]
主题词
AMP活化蛋白激酶类(AMP-Activated Protein Kinases);青少年(Adolescent);成年人(Adult);年龄因素(Age Factors);老年人(Aged);酰胺类(Amides);自身抗原(Autoantigens);细胞周期蛋白质类(Cell Cycle Proteins);染色体, 人, X(Chromosomes, Human, X);密码子, 无义(Codon, Nonsense);能量代谢(Energy Metabolism);脂肪酸类(Fatty Acids);女(雌)性(Female);基因频率(Gene Frequency);基因, X连锁(Genes, X-Linked);遗传变异(Genetic Variation);基因型(Genotype);人类(Humans);性腺功能减退症(Hypogonadism);免疫球蛋白类(Immunoglobulins);层黏连蛋白(Laminin);膜蛋白质类(Membrane Proteins);月经初潮(Menarche);中年人(Middle Aged);突变, 误义(Mutation, Missense);外显率(Penetrance);表型(Phenotype);蛋白质类(Proteins);RNA干扰(RNA Interference);RNA结合蛋白质类(RNA-Binding Proteins);受体, 神经激肽3(Receptors, Neurokinin-3);信号传导(Signal Transduction);青年人(Young Adult)
DOI
10.1038/ncomms8756
PMID
26239645
发布时间
2024-03-24
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Nature communications
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