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Rare coding variants and X-linked loci associated with age at menarche.

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作者: Kathryn L,Lunetta [1] ; Felix R,Day [2] ; Patrick,Sulem [3] ; Katherine S,Ruth [4] ; Joyce Y,Tung [5] ; David A,Hinds [5] ; Tõnu,Esko [6] ; Cathy E,Elks [2] ; Elisabeth,Altmaier [7] ; Chunyan,He [8] ; Jennifer E,Huffman [9] ; Evelin,Mihailov [10] ; Eleonora,Porcu [11] ; Antonietta,Robino [12] ; Lynda M,Rose [13] ; Ursula M,Schick [14] ; Lisette,Stolk [15] ; Alexander,Teumer [16] ; Deborah J,Thompson [17] ; Michela,Traglia [18] ; Carol A,Wang [19] ; Laura M,Yerges-Armstrong [20] ; Antonis C,Antoniou [17] ; Caterina,Barbieri [18] ; Andrea D,Coviello [21] ; Francesco,Cucca [22] ; Ellen W,Demerath [23] ; Alison M,Dunning [24] ; Ilaria,Gandin [25] ; Megan L,Grove [26] ; Daniel F,Gudbjartsson [27] ; Lynne J,Hocking [28] ; Albert,Hofman [29] ; Jinyan,Huang [30] ; Rebecca D,Jackson [31] ; David,Karasik [32] ; Jennifer,Kriebel [33] ; Ethan M,Lange [34] ; Leslie A,Lange [35] ; Claudia,Langenberg [2] ; Xin,Li [36] ; Jian'an,Luan [2] ; Reedik,Mägi [10] ; Alanna C,Morrison [26] ; Sandosh,Padmanabhan [37] ; Ailith,Pirie [17] ; Ozren,Polasek [38] ; David,Porteous [39] ; Alex P,Reiner [14] ; Fernando,Rivadeneira [40] ; Igor,Rudan [41] ; Cinzia F,Sala [18] ; David,Schlessinger [42] ; Robert A,Scott [2] ; Doris,Stöckl [43] ; Jenny A,Visser [15] ; Uwe,Völker [44] ; Diego,Vozzi [12] ; James G,Wilson [45] ; Marek,Zygmunt [46] ; EPIC-InterAct Consortium [26] ; Generation Scotland [47] ; Eric,Boerwinkle [48] ; Julie E,Buring [49] ; Laura,Crisponi [9] ; Douglas F,Easton [50] ; Caroline,Hayward [51] ; Frank B,Hu [52] ; Simin,Liu [19] ; Andres,Metspalu [47] ; Craig E,Pennell [53] ; Paul M,Ridker [20] ; Konstantin,Strauch [18] ; Elizabeth A,Streeten [40] ; Daniela,Toniolo [12] ; André G,Uitterlinden [16] ; Sheila,Ulivi [2] ; Henry,Völzke [54] ; Nicholas J,Wareham [55] ; Melissa,Wellons [47] ; Nora,Franceschini [56] ; Daniel I,Chasman [4] ; Unnur,Thorsteinsdottir [56] ; Anna,Murray [57] ; Kari,Stefansson [58] ; Joanne M,Murabito [2] ; Ken K,Ong ; John R B,Perry
作者单位: 1] Boston University School of Public Health, Department of Biostatistics, Boston, Massachusetts 02118, USA [2] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA. [1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK. [2] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland. [3] Genetics of Complex Traits, University of Exeter Medical School, University of Exeter, Exeter EX1 2LU, UK. [4] 23andMe Inc., 1390 Shorebird Way, Mountain View, California 94043, USA. [5] 1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Division of Endocrinology, Boston Children's Hospital, Boston, MA 02115, USA [3] Department of Genetics, Harvard Medical School, Boston, MA 02115, USA [4] Broad Institute of the Massachusetts Institute of Technology and Harvard University, 140, Cambridge, MA 02142, USA. [6] 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany. [7] 1] Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN 46202, USA [2] Indiana University Melvin and Bren Simon Cancer Center, Indianapolis, IN 46202, USA. [8] Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. [9] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia. [10] 1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy [3] Center for Statistical Genetics, Ann Arbor, University of Michigan, Michigan 48109-2029, USA. [11] Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste 34137, Italy. [12] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215. [13] Fred Hutchinson Cancer Research Center, Public Health Sciences Division, Seattle, WA 98109-1024, USA. [14] Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands. [15] Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany. [16] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK. [17] Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano 20132, Italy. [18] School of Women's and Infants' Health, The University of Western Australia, WA-6009, Australia. [19] Program in Personalized Medicine, Division of Endocrinology, Diabetes and Nutrition-University of Maryland School of Medicine, Baltimore, MD 21201, USA. [20] Boston University School of Medicine, Department of Medicine, Sections of Preventive Medicine and Endocrinology, Boston, MA, USA. [21] 1] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy [2] University of Sassari, Department of Biomedical Sciences, Sassari, Sassari 07100, Italy. [22] Division of Epidemiology &Community Health, University of Minnesotta, Minneapolis, MN 55455, USA. [23] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. [24] 1] Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", Trieste 34137, Italy [2] Department of Clinical Medical Sciences, Surgical and Health, University of Trieste, Trieste 34149, Italy. [25] Human Genetics Center, School of Public Health, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. [26] 1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] School of Engineering and Natural Sciences, University of Iceland, Reykjavik IS-101, Iceland. [27] Musculoskeletal Research Programme, Division of Applied Medicine, University of Aberdeen, Aberdeen AB25 2ZD, UK. [28] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands. [29] State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [30] Department of Internal Medicine, The Ohio State University, Columbus, Ohio 43210, USA. [31] 1] Hebrew SeniorLife Institute for Aging Research, Boston, MA 02131, USA [2] Harvard Medical School, Boston, MA 02115, USA. [32] 1] Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] German Center for Diabetes Research, Neuherberg 85764, Germany. [33] 1] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA [2] Department of Biostatistics, University of North Carolina, Chapel Hill, NC 27599, USA. [34] Department of Genetics, University of North Carolina, Chapel Hill, NC 27599, USA. [35] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA. [36] British Heart Foundation Glasgow Cardiovascular Research Centre, Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow G12 8TA, UK. [37] Faculty of Medicine, University of Split, Split, Croatia. [38] Medical Genetics Section, Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK. [39] 1] Department of Internal Medicine, Erasmus MC, Rotterdam 3015GE, the Netherlands [2] Genetic Epidemiology Unit Department of Epidemiology, Erasmus MC, Rotterdam 3015 GE, the Netherlands. [40] Institute for Population Health Sciences and Informatics, University of Edinburgh, Teviot Place, Edinburgh EH8 9AG, Scotland. [41] National Institute on Aging, Intramural Research Program, Baltimore, MD 20892, USA. [42] Institute of Epidemiology II, Helmholtz Zentrum München - German Research Center for Environmental Health, Neuherberg 85764, Germany. [43] Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald 17475, Germany. [44] Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, USA. [45] Department of Obstetrics and Gynecology, University Medicine Greifswald, Greifswald 17475, Germany. [46] 1] Division of Preventive Medicine, Brigham and Women's Hospital, Boston, MA 02215 [2] Harvard Medical School, Boston, MA 02115, USA. [47] Institute of Genetics and Biomedical Research, National Research Council, Cagliari, Sardinia 09042, Italy. [48] 1] Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, CB1 8RN, UK [2] Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge CB1 8RN, UK. [49] 1] Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA [2] Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA [3] Department of Nutrition, Harvard School of Public Health, Boston, MA 02115, USA. [50] Departments of Epidemiology and Medicine Brown University, Brown University, Providence, RI 02912, USA. [51] 1] Estonian Genome Center, University of Tartu, Tartu 51010, Estonia [2] Institute of Molecular and Cell Biology, University of Tartu, Tartu 51010, Estonia. [52] 1] Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg 85764, Germany [2] Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich 81377, Germany. [53] Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee 37203, USA. [54] Department of Epidemiology, University of North Carolina, Chapel Hill, NC 27599, USA. [55] 1] deCODE genetics/Amgen, Inc., Reykjavik IS-101, Iceland [2] Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland. [56] 1] NHLBI's and Boston University's Framingham Heart Study, Framingham, Massachusetts 01702-5827, USA [2] Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine, Boston, MA 02118, USA. [57] 1] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Box 285 Institute of Metabolic Science, Cambridge Biomedical Campus, Cambridge CB2 0QQ, UK [2] Department of Paediatrics, University of Cambridge, Cambridge CB2 0QQ, UK. [58]
DOI 10.1038/ncomms8756
PMID 26239645
发布时间 2024-03-24
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