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首页> The Journal of biological chemistry> All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling.

All-trans-retinoic acid reduces BACE1 expression under inflammatory conditions via modulation of nuclear factor κB (NFκB) signaling.

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作者： Ruishan,Wang ^[1] ; Shaoya,Chen ^[2] ; Yingchun,Liu ^[2] ; Shiyong,Diao ^[2] ; Yueqiang,Xue ^[2] ; Xiaoqing,You ^[3] ; Edwards A,Park ^[4] ; Francesca-Fang,Liao ^[5]

作者单位： From the Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, rwang11@uthsc.edu. ^[1] From the Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163. ^[2] the Division of Cell Biology and Genetics, Fujian Medical University, Fuzhou 350004, China. ^[3] From the Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, the Department of Veterans Affairs Medical Center, Memphis, Tennessee 38163, and. ^[4] From the Department of Pharmacology, University of Tennessee Health Science Center, Memphis, Tennessee 38163, fliao@uthsc.edu. ^[5]

关键词 Alzheimer disease NFkappa B (NFKB)beta-secretase 1 (BACE1)gene transcription retinoic acid retinoid signaling

主题词阿尔茨海默病(Alzheimer Disease);淀粉样前体蛋白分泌酶类(Amyloid Precursor Protein Secretases);动物(Animals);天冬氨酸内肽酶类(Aspartic Acid Endopeptidases);脑(Brain);膳食脂肪类(Dietary Fats);疾病模型, 动物(Disease Models, Animal);基因表达调控, 酶学(Gene Expression Regulation, Enzymologic);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);NF-κB(NF-kappa B);信号传导(Signal Transduction);维甲酸(Tretinoin)

DOI 10.1074/jbc.M115.662908

PMID 26240147

发布时间 2022-03-30

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The Journal of biological chemistry

The Journal of biological chemistry

2015年290卷37期

22532-42页

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