Early treatment with UR13870, a novel inhibitor of p38α mitogenous activated protein kinase, prevents hyperreflexia and anxiety behaviors, in the spared nerve injury model of neuropathic pain.

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第一作者： Iriana,Galan-Arriero

第一单位： Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Escuela Internacional de Doctorado (EID), Universidad Rey Juan Carlos I. Móstoles, Madrid, Spain. Electronic address: igalan@jccm.es.

作者： Iriana,Galan-Arriero ^[1] ; Gerardo,Avila-Martin ^[2] ; Agueda,Ferrer-Donato ^[3] ; Julio,Gomez-Soriano ^[4] ; Stefano,Piazza ^[5] ; Julian,Taylor ^[6]

作者单位： Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Escuela Internacional de Doctorado (EID), Universidad Rey Juan Carlos I. Móstoles, Madrid, Spain. Electronic address: igalan@jccm.es. ^[1] Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. Electronic address: gavila@sescam.jccm.es. ^[2] Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain. Electronic address: agata9364@hotmail.com. ^[3] Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Escuela de Enfermeria y Fisioterapia Universidad Castilla La Mancha, Toledo, Spain. Electronic address: Julio.Soriano@uclm.es. ^[4] Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Neural Rehabilitation Group, Cajal Institute CSIC, Madrid, Spain. Electronic address: stefano.piazza@csic.es. ^[5] Sensorimotor Function Group, Hospital Nacional de Parapléjicos, SESCAM, Toledo, Spain; Stoke Mandeville Spinal Research, National Spinal Injuries Centre, Buckinghamshire Healthcare Trust, Stoke Mandeville, Aylesbury, UK; Harris Manchester College, University of Oxford, Oxford, UK. Electronic address: jscott@sescam.org. ^[6]

关键词 Antinociception Microglia Neuropathic pain OX-42 Open field induced anxiety test Place escape/avoidance paradigm Spared nerve injury p38α MAPK inhibitor