Development of a Sustained Release Solid Dispersion Using Swellable Polymer by Melting Method.

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作者： Tuong Ngoc-Gia,Nguyen ^[1] ; Phuong Ha-Lien,Tran ^[2] ; Toi,Van Vo ^[3] ; Wei,Duan ^[1] ; Thao,Truong-Dinh Tran ^[4]

作者单位： Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam. ^[1] Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam. phuong.tran1@deakin.edu.au. ^[2] School of Medicine, Deakin University, Waurn Ponds, VIC, Australia. phuong.tran1@deakin.edu.au. ^[3] School of Medicine, Deakin University, Waurn Ponds, VIC, Australia. ^[4] Pharmaceutical Engineering Laboratory, Biomedical Engineering Department, International University, Vietnam National University, Ho Chi Minh City, Vietnam. ttdthao@hcmiu.edu.vn. ^[5] Institute for Frontier Materials, Deakin University, Waurn Ponds, VIC, Australia. ttdthao@hcmiu.edu.vn. ^[6]

关键词 poorly water-soluble drug solid dispersion sustained release swellable polymer

主题词化学, 药物(Chemistry, Pharmaceutical);迟效制剂(Delayed-Action Preparations);药物设计(Drug Design);聚乙烯二醇类(Polyethylene Glycols);溶解度(Solubility);片剂(Tablets);X线衍射(X-Ray Diffraction)

DOI 10.1007/s11095-015-1767-2

PMID 26264511

发布时间 2018-12-02

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