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首页> Science (New York, N.Y.)> RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.

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第一作者： Brian J,Liddicoat

第一单位： St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia. Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia.

作者： Brian J,Liddicoat ^[1] ; Robert,Piskol ^[2] ; Alistair M,Chalk ^[1] ; Gokul,Ramaswami ^[2] ; Miyoko,Higuchi ^[3] ; Jochen C,Hartner ^[4] ; Jin Billy,Li ^[2] ; Peter H,Seeburg ^[3] ; Carl R,Walkley ^[5]

作者单位： St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia. Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia. ^[1] Department of Genetics, Stanford University, Stanford, CA 94305, USA. ^[2] Department of Molecular Neurobiology, Max Planck Institute for Medical Research, 69120 Heidelberg, Germany. ^[3] Taconic Biosciences, 51063 Cologne, Germany. ^[4] St. Vincent's Institute of Medical Research, Fitzroy, Victoria 3065, Australia. Department of Medicine, St. Vincent's Hospital, University of Melbourne, Fitzroy, Victoria 3065, Australia. cwalkley@svi.edu.au. ^[5]

主题词 3'非翻译区(3' Untranslated Regions);腺苷(Adenosine);腺苷脱氨酶(Adenosine Deaminase);动物(Animals);DEAD-box RNA解旋酶类(DEAD-box RNA Helicases);胚胎丢失(Embryo Loss);基因缺失(Gene Deletion);基因敲入技术(Gene Knock-In Techniques);肌苷(Inosine);小鼠(Mice);小鼠, 突变型(Mice, Mutant Strains);突变(Mutation);核酸构象(Nucleic Acid Conformation);RNA编辑(RNA Editing);RNA, 双链(RNA, Double-Stranded);转录, 遗传(Transcription, Genetic)

DOI 10.1126/science.aac7049

PMID 26275108

发布时间 2024-06-19

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Science (New York, N.Y.)

Science (New York, N.Y.)

2015年349卷6252期

1115-20页

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