作者：
Ganesh,Kolumam [1]
;
Mark Z,Chen [1]
;
Raymond,Tong [2]
;
Jose,Zavala-Solorio [1]
;
Lance,Kates [1]
;
Nicholas,van Bruggen [3]
;
Jed,Ross [3]
;
Shelby K,Wyatt [3]
;
Vineela D,Gandham [3]
;
Richard A D,Carano [3]
;
Diana Ronai,Dunshee [1]
;
Ai-Luen,Wu [1]
;
Benjamin,Haley [1]
;
Keith,Anderson [1]
;
Søren,Warming [1]
;
Xin Y,Rairdan [4]
;
Nicholas,Lewin-Koh [5]
;
Yingnan,Zhang [6]
;
Johnny,Gutierrez [7]
;
Amos,Baruch [7]
;
Thomas R,Gelzleichter [8]
;
Dale,Stevens [8]
;
Sharmila,Rajan [9]
;
Travis W,Bainbridge [2]
;
Jean-Michel,Vernes [10]
;
Y Gloria,Meng [10]
;
James,Ziai [11]
;
Robert H,Soriano [1]
;
Matthew J,Brauer [12]
;
Yongmei,Chen [13]
;
Scott,Stawicki [13]
;
Hok Seon,Kim [13]
;
Laëtitia,Comps-Agrar [10]
;
Elizabeth,Luis [2]
;
Christoph,Spiess [13]
;
Yan,Wu [13]
;
James A,Ernst [2]
;
Owen P,McGuinness [14]
;
Andrew S,Peterson [1]
;
Junichiro,Sonoda [1]
作者单位：
Molecular Biology, Genentech, Inc., South San Francisco, CA 94080, USA.
[1]
Protein Chemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
[2]
Biomedical Imaging, Genentech, Inc., South San Francisco, CA 94080, USA.
[3]
Transgenic Technology, Genentech, Inc., South San Francisco, CA 94080, USA.
[4]
Biostatistics, Genentech, Inc., South San Francisco, CA 94080, USA.
[5]
Early Discovery Biochemistry, Genentech, Inc., South San Francisco, CA 94080, USA.
[6]
ITGR/NTA Pharmacodynamic Biomarkers, Genentech, Inc., South San Francisco, CA 94080, USA.
[7]
Safety Assessment, Genentech, Inc., South San Francisco, CA 94080, USA.
[8]
Preclinical & Translational Pharmacokinetics, Genentech, Inc., South San Francisco, CA 94080, USA.
[9]
Biochemical and Cellular Pharmacology, Genentech, Inc., South San Francisco, CA 94080, USA.
[10]
Pathology, Genentech, Inc., South San Francisco, CA 94080, USA.
[11]
Bioinformatics and Computational Biology, Genentech, Inc., South San Francisco, CA 94080, USA.
[12]
Antibody Engineering, Genentech, Inc., South San Francisco, CA 94080, USA.
[13]
Department of Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, TN 37232, USA.
[14]
主题词
脂联素(Adiponectin);脂肪组织, 棕色(Adipose Tissue, Brown);动物(Animals);抗体, 双特异性(Antibodies, Bispecific);细胞系(Cell Line);能量代谢(Energy Metabolism);成纤维细胞生长因子(Fibroblast Growth Factors);HEK293细胞(HEK293 Cells);人类(Humans);胰岛素(Insulin);成束猴(Macaca fascicularis);男(雄)性(Male);膜蛋白质类(Membrane Proteins);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 肥胖(Mice, Obese);蛋白质结合(Protein Binding);受体, 成纤维细胞生长因子, 1型(Receptor, Fibroblast Growth Factor, Type 1);产热(Thermogenesis);体重减轻(Weight Loss)
DOI
10.1016/j.ebiom.2015.05.028
PMID
26288846
发布时间
2022-03-17
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