Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.

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作者： Shengliang,Zhang ^[1] ; Lanlan,Zhou ^[1] ; Bo,Hong ^[2] ; A Pieter J,van den Heuvel ^[2] ; Varun V,Prabhu ^[1] ; Noel A,Warfel ^[2] ; Christina Leah B,Kline ^[1] ; David T,Dicker ^[1] ; Levy,Kopelovich ^[3] ; Wafik S,El-Deiry ^[4]

作者单位： Penn State Hershey Cancer Institute, Hershey, Pennsylvania. Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medical Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. ^[1] Penn State Hershey Cancer Institute, Hershey, Pennsylvania. ^[2] Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland. ^[3] Penn State Hershey Cancer Institute, Hershey, Pennsylvania. Laboratory of Translational Oncology and Experimental Cancer Therapeutics, Department of Medical Oncology and Molecular Therapeutics Program, Fox Chase Cancer Center, Philadelphia, Pennsylvania. wafik.eldeiry@gmail.com. ^[4]