Development of an S-1 dosage formula based on renal function by a prospective pharmacokinetic study.

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第一作者： Eisuke,Booka

第一单位： Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.

作者： Eisuke,Booka ^[1] ; Chiyo K,Imamura ^[2] ; Hiroya,Takeuchi ^[1] ; Yasuo,Hamamoto ^[3] ; Daisuke,Gomi ^[4] ; Takuro,Mizukami ^[5] ; Takashi,Ichiyama ^[6] ; Kazunari,Tateishi ^[6] ; Tsunehiro,Takahashi ^[7] ; Hirofumi,Kawakubo ^[1] ; Kenzo,Soejima ^[8] ; Narikazu,Boku ^[5] ; Yusuke,Tanigawara ^[9] ; Yuko,Kitagawa ^[7]

作者单位： Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[1] Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. imamurack@z3.keio.jp. ^[2] Keio Cancer Center, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[3] Department of Comprehensive Cancer Therapy, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. ^[4] Department of Clinical Oncology, St. Marianna University School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki, Kanagawa, 216-8511, Japan. ^[5] First Department of Internal Medicine, Shinshu University School of Medicine, 3-1-1 Asahi, Matsumoto, Nagano, 390-8621, Japan. ^[6] Department of Surgery, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.;Keio Cancer Center, Keio University Hospital, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[7] Division of Pulmonary Medicine, Department of Medicine, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[8] Department of Clinical Pharmacokinetics and Pharmacodynamics, School of Medicine, Keio University, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan. ^[9]

关键词 Creatinine clearance Dosage formula Population pharmacokinetics Renal function S-1