首页> Journal of medicinal chemistry> Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.

Synthesis and Pharmacological Characterization of C4-(Thiotriazolyl)-substituted-2-aminobicyclo[3.1.0]hexane-2,6-dicarboxylates. Identification of (1R,2S,4R,5R,6R)-2-Amino-4-(1H-1,2,4-triazol-3-ylsulfanyl)bicyclo[3.1.0]hexane-2,6-dicarboxylic Acid (LY2812223), a Highly Potent, Functionally Selective mGlu2 Receptor Agonist.

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第一作者： James A,Monn

第一单位： Discovery Chemistry Research and Technologies, ‡Quantitative Biology, §Structural Biology, ∥Drug Disposition and ⊥Neuroscience Research, Eli Lilly and Company , Lilly Corporate Center, Drop 0510, Indianapolis, Indiana 46285, United States.

作者： James A,Monn ^[1] ; Lourdes,Prieto ^[1] ; Lorena,Taboada ^[1] ; Junliang,Hao ^[1] ; Matthew R,Reinhard ^[1] ; Steven S,Henry ^[1] ; Christopher D,Beadle ^[1] ; Lesley,Walton ^[1] ; Teresa,Man ^[1] ; Helene,Rudyk ^[1] ; Barry,Clark ^[1] ; David,Tupper ^[1] ; S Richard,Baker ^[1] ; Carlos,Lamas ^[1] ; Carlos,Montero ^[1] ; Alicia,Marcos ^[1] ; Jaime,Blanco ^[1] ; Mark,Bures ^[1] ; David K,Clawson ^[1] ; Shane,Atwell ^[1] ; Frances,Lu ^[1] ; Jing,Wang ^[1] ; Marijane,Russell ^[1] ; Beverly A,Heinz ^[1] ; Xushan,Wang ^[1] ; Joan H,Carter ^[1] ; Brian G,Getman ^[1] ; John T,Catlow ^[1] ; Steven,Swanson ^[1] ; Bryan G,Johnson ^[1] ; David B,Shaw ^[1] ; David L,McKinzie ^[1]

作者单位： Discovery Chemistry Research and Technologies, ‡Quantitative Biology, §Structural Biology, ∥Drug Disposition and ⊥Neuroscience Research, Eli Lilly and Company , Lilly Corporate Center, Drop 0510, Indianapolis, Indiana 46285, United States. ^[1]