Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.-论文-万方医学网

第一作者： Vincent,Hurez

第一单位： Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.

作者： Vincent,Hurez ^[1] ; Vinh,Dao ^[2] ; Aijie,Liu ^[1] ; Srilakshmi,Pandeswara ^[1] ; Jonathan,Gelfond ^[3] ; Lishi,Sun ^[2] ; Molly,Bergman ^[2] ; Carlos J,Orihuela ^[2] ; Veronica,Galvan ^[4] ; Álvaro,Padrón ^[1] ; Justin,Drerup ^[2] ; Yang,Liu ^[1] ; Paul,Hasty ^[5] ; Zelton Dave,Sharp ^[6] ; Tyler J,Curiel ^[7]

作者单位： Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA. ^[1] Graduate School of Biomedical Sciences, University of Texas Health Science Center, San Antonio, TX, USA. ^[2] Department of Epidemiology and Biostatistics, University of Texas Health Science Center, San Antonio, TX, USA. ^[3] Graduate School of Biomedical Sciences, University of Texas Health Science Center, San Antonio, TX, USA.;Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA.;Department of Physiology, University of Texas Health Science Center, San Antonio, TX, USA. ^[4] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA.;Department of Molecular Medicine, Institute of Biotechnology, University of Texas Health Science Center, San Antonio, TX, USA. ^[5] Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA. ^[6] Department of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.;Graduate School of Biomedical Sciences, University of Texas Health Science Center, San Antonio, TX, USA.;Barshop Institute for Longevity and Aging Studies, University of Texas Health Science Center, San Antonio, TX, USA.;Cancer Therapy & Research Center, University of Texas Health Science Center, San Antonio, TX, USA. ^[7]

医学主题词衰老(Aging);动物(Animals);抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);B-淋巴细胞(B-Lymphocytes);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);细胞分化(Cell Differentiation);树突细胞(Dendritic Cells);女(雌)性(Female);鞭毛蛋白(Flagellin);基因表达谱(Gene Expression Profiling);免疫记忆(Immunologic Memory);白细胞介素类(Interleukins);长寿(Longevity);男(雄)性(Male);黑色素瘤, 实验性(Melanoma, Experimental);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);髓系细胞(Myeloid Cells);西罗莫司(Sirolimus);脾(Spleen);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases)

DOI 10.1111/acel.12380

PMID 26315673

发布时间 2024-05-31

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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.

Aging cell

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Chronic mTOR inhibition in mice with rapamycin alters T, B, myeloid, and innate lymphoid cells and gut flora and prolongs life of immune-deficient mice.

Aging cell

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同项目论文

Aging cell

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