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Inhibiting DNA Methylation Causes an Interferon Response in Cancer via dsRNA Including Endogenous Retroviruses.

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第一作者： Katherine B,Chiappinelli

第一单位： Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA.

作者： Katherine B,Chiappinelli ^[1] ; Pamela L,Strissel ^[2] ; Alexis,Desrichard ^[3] ; Huili,Li ^[1] ; Christine,Henke ^[2] ; Benjamin,Akman ^[1] ; Alexander,Hein ^[2] ; Neal S,Rote ^[4] ; Leslie M,Cope ^[1] ; Alexandra,Snyder ^[5] ; Vladimir,Makarov ^[3] ; Sadna,Budhu ^[6] ; Dennis J,Slamon ^[7] ; Jedd D,Wolchok ^[1] ; Drew M,Pardoll ^[2] ; Matthias W,Beckmann ^[1] ; Cynthia A,Zahnow ^[5] ; Taha,Merghoub ^[8] ; Timothy A,Chan ^[9] ; Stephen B,Baylin ; Reiner,Strick

作者单位： Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. ^[1] Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University-Clinic Erlangen, 91054 Erlangen, Germany. ^[2] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[3] Department of Reproductive Biology, Case Western Reserve University, Cleveland, OH 44106, USA. ^[4] Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA; Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[5] The Jonsson Comprehensive Cancer Center, University of California-Los Angeles, Los Angeles, CA 90095, USA. ^[6] Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA. ^[7] Department of Oncology, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD 21287, USA. Electronic address: sbaylin@jhmi.edu. ^[8] Department of Gynaecology and Obstetrics, Laboratory for Molecular Medicine, University-Clinic Erlangen, 91054 Erlangen, Germany. Electronic address: reiner.strick@uk-erlangen.de. ^[9]