A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment.-论文-万方医学网

第一作者： Zhuang,Li

第一单位： National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China.

作者： Zhuang,Li ^[1] ; Yue,Cheng ^[1] ; Hualong,Xi ^[1] ; Tiejun,Gu ^[2] ; Ruosen,Yuan ^[1] ; Xiaoxu,Chen ^[1] ; Chunlai,Jiang ^[2] ; Wei,Kong ^[3] ; Yongge,Wu ^[4]

作者单位： National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China. ^[1] National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun 130012, China. ^[2] National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun 130012, China. Electronic address: weikong@jlu.edu.cn. ^[3] National Engineering Laboratory for AIDS Vaccine, School of Life Science, Jilin University, Changchun 130012, China; Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education, School of Life Science, Jilin University, Changchun 130012, China. Electronic address: ygwu@jlu.edu.cn. ^[4]

主题词动物(Animals);抗体, 中和(Antibodies, Neutralizing);仓鼠属(Cricetulus);大肠杆菌(Escherichia coli);女(雌)性(Female);基因表达(Gene Expression);HEK293细胞(HEK293 Cells);人类(Humans);免疫法(Immunization);免疫球蛋白G(Immunoglobulin G);亮氨酸拉链(Leucine Zippers);小鼠(Mice);中和试验(Neutralization Tests);质粒(Plasmids);蛋白质多聚化(Protein Multimerization);狂犬病(Rabies);狂犬病疫苗(Rabies Vaccines);狂犬病病毒(Rabies virus);重组蛋白质类(Recombinant Proteins);单链抗体(Single-Chain Antibodies);存活率分析(Survival Analysis);病毒包膜蛋白质类(Viral Envelope Proteins)

DOI 10.1016/j.molimm.2015.06.027

PMID 26325475

发布时间 2015-10-27

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A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment.

Molecular immunology

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Molecular immunology

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A novel variable antibody fragment dimerized by leucine zippers with enhanced neutralizing potency against rabies virus G protein compared to its corresponding single-chain variable antibody fragment.

Molecular immunology

相似文献

Molecular immunology

相关期刊

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