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首页> Neurobiology of learning and memory> Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.

Environmental enrichment improves learning and memory and long-term potentiation in young adult rats through a mechanism requiring mGluR5 signaling and sustained activation of p70s6k.

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作者： Rikki,Hullinger ^[1] ; Kenneth,O'Riordan ^[2] ; Corinna,Burger ^[3]

作者单位： Neuroscience Training Program, University of Wisconsin-Madison, USA. ^[1] Department of Pharmacology & Therapeutics, Biotechnology (Watts) Building, Trinity College, Dublin 2, Ireland(1). ^[2] Department of Neurology, University of Wisconsin-Madison, Medical Sciences Center, 1300 University Ave, Room 73 Bardeen, Madison, WI 53706, USA; Neuroscience Training Program, University of Wisconsin-Madison, USA. Electronic address: burger@neurology.wisc.edu. ^[3]

关键词 Environmental enrichment Metabotropic glutamate receptor Morris water maze Object recognition Young rats p70s6 kinase

主题词动物(Animals);环境(Environment);兴奋性氨基酸拮抗剂(Excitatory Amino Acid Antagonists);兴奋性突触后电位(Excitatory Postsynaptic Potentials);动物房(Housing, Animal);学习(Learning);长时程增强(Long-Term Potentiation);记忆(Memory);磷酰化(Phosphorylation);吡啶类(Pyridines);大鼠(Rats);核糖体蛋白质S6激酶类, 70-kDa(Ribosomal Protein S6 Kinases, 70-kDa);信号传导(Signal Transduction)

DOI 10.1016/j.nlm.2015.08.006

PMID 26341144

发布时间 2018-11-13

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Neurobiology of learning and memory

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