Structure-dependent inhibition of the human α1β2γ2 GABAA receptor by piperazine derivatives: A novel mode of action.

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作者： Laura,Hondebrink ^[1] ; Elise J P,Hermans ^[2] ; Stijn,Schmeink ^[3] ; Regina G D M,van Kleef ^[4] ; Jan,Meulenbelt ^[5] ; Remco H S,Westerink ^[6]

作者单位： National Poisons Information Center (NVIC), University Medical Center Utrecht, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands. Electronic address: L.Hondebrink@umcutrecht.nl. ^[1] Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 Utrecht, The Netherlands. Electronic address: E.J.P.hermans@uu.nl. ^[2] Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 Utrecht, The Netherlands. Electronic address: S.Schmeink@uu.nl. ^[3] Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 Utrecht, The Netherlands. Electronic address: G.vankleef@uu.nl. ^[4] National Poisons Information Center (NVIC), University Medical Center Utrecht, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands; Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 Utrecht, The Netherlands; Department of Intensive Care Medicine, University Medical Center Utrecht, P.O. Box 85500, NL-3508 GA Utrecht, The Netherlands. Electronic address: J.Meulenbelt-1@umcutrecht.nl. ^[5] Neurotoxicology Research Group, Division Toxicology, Institute for Risk Assessment Sciences (IRAS), Faculty of Veterinary Medicine, Utrecht University, P.O. Box 80.177, NL-3508 Utrecht, The Netherlands. Electronic address: R.Westerink@uu.nl. ^[6]

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