IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.

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作者： Pengyan,Xia ^[1] ; Shuo,Wang ^[1] ; Zhen,Xiong ^[1] ; Buqing,Ye ^[2] ; Li-Yu,Huang ^[1] ; Ze-Guang,Han ^[3] ; Zusen,Fan ^[4]

作者单位： Key Laboratory of Infection and Immunity of CAS, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China. ^[1] University of Chinese Academy of Sciences, No.19A Yuquan Road, Beijing 100049, China. ^[2] Key Laboratory of Systems Biomedicine (Ministry of Education) and Collaborative Innovation Center of Systems Biomedicine, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China. ^[3] Shanghai-MOST Key Laboratory for Disease and Health Genomics, Chinese National Human Genome Center at Shanghai, 351 Guo Shou-Jing Road, Shanghai 201203, China. ^[4]

主题词衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);动物(Animals);DEAD-box RNA解旋酶类(DEAD-box RNA Helicases);减量调节(Down-Regulation);成纤维细胞(Fibroblasts);荧光抗体技术(Fluorescent Antibody Technique);免疫, 先天(Immunity, Innate);免疫沉淀法(Immunoprecipitation);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);微丝蛋白质类(Microfilament Proteins);蛋白质转运(Protein Transport);RNA结合蛋白质类(RNA-Binding Proteins);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);弹状病毒科感染(Rhabdoviridae Infections);SUMO化(Sumoylation);泛素缀合酶类(Ubiquitin-Conjugating Enzymes);水疱病毒属(Vesiculovirus)

DOI 10.1038/ncomms9132

PMID 26348439

发布时间 2019-04-24

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Nature communications

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IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.

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IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation.

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