Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.-论文-万方医学网

作者： Yaochen,Zhang ^[1] ; Don-Kyu,Kim ^[1] ; Ji-Min,Lee ^[1] ; Seung Bum,Park ^[2] ; Won-Il,Jeong ^[3] ; Seong Heon,Kim ^[4] ; In-Kyu,Lee ^[5] ; Chul-Ho,Lee ^[6] ; John Y L,Chiang ^[7] ; Hueng-Sik,Choi ^[8]

作者单位： National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea. ^[1] Chemical Biology Laboratory, School of Chemistry, Seoul National University, Seoul 151-742, Republic of Korea. ^[2] Laboratory of Liver Research, Graduate School of Medical Science and Engineering, KAIST, Daejeon 305-338, Republic of Korea. ^[3] New Drug Development Center, Daegu-Gyeongbuk Medical Innovation Foundation, Daegu 701-310, Republic of Korea. ^[4] Department of Internal Medicine, Kyungpook National University School of Medicine, Daegu 700-721, Republic of Korea. ^[5] Korea Research Institute of Bioscience and Biotechnology, Daejeon 305-806, Republic of Korea. ^[6] Department of Integrative Medical Sciences, Northeastern Ohio University's Colleges of Medicine and Pharmacy, Rootstown, Ohio 44272, U.S.A. ^[7] National Creative Research Initiatives Center for Nuclear Receptor Signals and Hormone Research Center, School of Biological Sciences and Technology, Chonnam National University, Gwangju 500-757, Republic of Korea hsc@chonnam.ac.kr. ^[8]

主题词动物(Animals);胆汁酸类和盐类(Bile Acids and Salts);细胞, 培养的(Cells, Cultured);胆固醇7-α-羟化酶(Cholesterol 7-alpha-Hydroxylase);药物反向激动作用(Drug Inverse Agonism);乙醇(Ethanol);基因表达(Gene Expression);甘油酯类(Glycerides);HEK293细胞(HEK293 Cells);肝细胞(Hepatocytes);人类(Humans);肝(Liver);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);启动区, 遗传(Promoter Regions, Genetic);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 大麻酚, CB1(Receptor, Cannabinoid, CB1);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);受体, 雌激素(Receptors, Estrogen);转录, 遗传(Transcription, Genetic)

DOI 10.1042/BJ20141494

PMID 26348907

发布时间 2024-06-10

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Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.

The Biochemical journal

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Orphan nuclear receptor oestrogen-related receptor γ (ERRγ) plays a key role in hepatic cannabinoid receptor type 1-mediated induction of CYP7A1 gene expression.

The Biochemical journal

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The Biochemical journal

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