换一批
换一批Efflux transporters at the blood-brain barrier limit delivery and efficacy of cyclin-dependent kinase 4/6 inhibitor palbociclib (PD-0332991) in an orthotopic brain tumor model.
第一作者：
Karen E,Parrish
第一单位：
Department of Pharmaceutics, Brain Barriers Research Center, University of Minnesota, Minneapolis, Minnesota (K.E.P., R.K.M., W.F.E.); and Department of Radiation Oncology, Mayo Clinic, Rochester, Minnesota (J.P., K.B., J.N.S.).
作者：
主题词
ATP结合匣式转运子(ATP-Binding Cassette Transporters);吖啶类(Acridines);动物(Animals);抗肿瘤药(Antineoplastic Agents);血脑屏障(Blood-Brain Barrier);脑肿瘤(Brain Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞周期蛋白依赖激酶4(Cyclin-Dependent Kinase 4);细胞周期蛋白依赖激酶6(Cyclin-Dependent Kinase 6);狗(Dogs);抗药性, 肿瘤(Drug Resistance, Neoplasm);药物协同作用(Drug Synergism);女(雌)性(Female);胶质母细胞瘤(Glioblastoma);男(雄)性(Male);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);小鼠, 裸(Mice, Nude);肿瘤移植(Neoplasm Transplantation);哌嗪类(Piperazines);吡啶类(Pyridines);四氢异喹啉类(Tetrahydroisoquinolines)
DOI
10.1124/jpet.115.228213
PMID
26354993
发布时间
2025-03-06
- 浏览55
相似文献
- 中文期刊
- 外文期刊
- 学位论文
- 会议论文
