Simultaneous determination of hydrophobicity and dissociation constant for a large set of compounds by gradient reverse phase high performance liquid chromatography-mass spectrometry technique.

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第一作者： Łukasz,Kubik

第一单位： Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland.

作者： Łukasz,Kubik ^[1] ; Wiktoria,Struck-Lewicka ^[1] ; Roman,Kaliszan ^[1] ; Paweł,Wiczling ^[2]

作者单位： Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland. ^[1] Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdańsk, Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address: wiczling@gumed.edu.pl. ^[2]

关键词 Acidity Gradient RP HPLC Hydrophobicity Throughput analysis pH/organic modifier

主题词色谱法, 高压液相(Chromatography, High Pressure Liquid);色谱法, 反相(Chromatography, Reverse-Phase);氢离子浓度(Hydrogen-Ion Concentration);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);药用制剂(Pharmaceutical Preparations);光谱法, 质量, 电喷雾电离(Spectrometry, Mass, Electrospray Ionization)

DOI 10.1016/j.chroma.2015.09.003

PMID 26365909

发布时间 2018-12-02

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