换一批
第一作者：
Hou-Feng,Zheng
第一单位：
Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.;Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.
作者：
Hou-Feng,Zheng [1]
;
Vincenzo,Forgetta [1]
;
Yi-Hsiang,Hsu [2]
;
Karol,Estrada [3]
;
Alberto,Rosello-Diez [4]
;
Paul J,Leo [5]
;
Chitra L,Dahia [6]
;
Kyung Hyun,Park-Min [7]
;
Jonathan H,Tobias [8]
;
Charles,Kooperberg [9]
;
Aaron,Kleinman [10]
;
Unnur,Styrkarsdottir [11]
;
Ching-Ti,Liu [12]
;
Charlotta,Uggla [13]
;
Daniel S,Evans [14]
;
Carrie M,Nielson [15]
;
Klaudia,Walter [16]
;
Ulrika,Pettersson-Kymmer [17]
;
Shane,McCarthy [16]
;
Joel,Eriksson [18]
;
Tony,Kwan [19]
;
Mila,Jhamai [20]
;
Katerina,Trajanoska [21]
;
Yasin,Memari [16]
;
Josine,Min [22]
;
Jie,Huang [16]
;
Petr,Danecek [16]
;
Beth,Wilmot [23]
;
Rui,Li [1]
;
Wen-Chi,Chou [24]
;
Lauren E,Mokry [25]
;
Alireza,Moayyeri [26]
;
Melina,Claussnitzer [27]
;
Chia-Ho,Cheng [28]
;
Warren,Cheung [29]
;
Carolina,Medina-Gómez [30]
;
Bing,Ge [19]
;
Shu-Huang,Chen [19]
;
Kwangbom,Choi [31]
;
Ling,Oei [30]
;
James,Fraser [32]
;
Robert,Kraaij [30]
;
Matthew A,Hibbs [33]
;
Celia L,Gregson [34]
;
Denis,Paquette [32]
;
Albert,Hofman [35]
;
Carl,Wibom [36]
;
Gregory J,Tranah [15]
;
Mhairi,Marshall [5]
;
Brooke B,Gardiner [5]
;
Katie,Cremin [5]
;
Paul,Auer [37]
;
Li,Hsu [9]
;
Sue,Ring [38]
;
Joyce Y,Tung [10]
;
Gudmar,Thorleifsson [39]
;
Anke W,Enneman [20]
;
Natasja M,van Schoor [40]
;
Lisette C P G M,de Groot [41]
;
Nathalie,van der Velde [42]
;
Beatrice,Melin [36]
;
John P,Kemp [43]
;
Claus,Christiansen [44]
;
Adrian,Sayers [34]
;
Yanhua,Zhou [12]
;
Sophie,Calderari [45]
;
Jeroen,van Rooij [46]
;
Chris,Carlson [9]
;
Ulrike,Peters [9]
;
Soizik,Berlivet [32]
;
Josée,Dostie [32]
;
Andre G,Uitterlinden [30]
;
Stephen R,Williams [47]
;
Charles,Farber [47]
;
Daniel,Grinberg [48]
;
Andrea Z,LaCroix [49]
;
Jeff,Haessler [9]
;
Daniel I,Chasman [50]
;
Franco,Giulianini [51]
;
Lynda M,Rose [51]
;
Paul M,Ridker [50]
;
John A,Eisman [52]
;
Tuan V,Nguyen [53]
;
Jacqueline R,Center [53]
;
Xavier,Nogues [54]
;
Natalia,Garcia-Giralt [55]
;
Lenore L,Launer [56]
;
Vilmunder,Gudnason [57]
;
Dan,Mellström [13]
;
Liesbeth,Vandenput [13]
;
Najaf,Amin [58]
;
Cornelia M,van Duijn [58]
;
Magnus K,Karlsson [59]
;
Östen,Ljunggren [60]
;
Olle,Svensson [61]
;
Göran,Hallmans [62]
;
François,Rousseau [63]
;
Sylvie,Giroux [64]
;
Johanne,Bussière [64]
;
Pascal P,Arp [20]
;
Fjorda,Koromani [21]
;
Richard L,Prince [65]
;
Joshua R,Lewis [65]
;
Bente L,Langdahl [66]
;
A Pernille,Hermann [67]
;
Jens-Erik B,Jensen [68]
;
Stephen,Kaptoge [69]
;
Kay-Tee,Khaw [70]
;
Jonathan,Reeve [71]
;
Melissa M,Formosa [72]
;
Angela,Xuereb-Anastasi [72]
;
Kristina,Åkesson [73]
;
Fiona E,McGuigan [74]
;
Gaurav,Garg [74]
;
Jose M,Olmos [75]
;
Maria T,Zarrabeitia [76]
;
Jose A,Riancho [75]
;
Stuart H,Ralston [77]
;
Nerea,Alonso [77]
;
Xi,Jiang [78]
;
David,Goltzman [79]
;
Tomi,Pastinen [29]
;
Elin,Grundberg [29]
;
Dominique,Gauguier [45]
;
Eric S,Orwoll [80]
;
David,Karasik [81]
;
George,Davey-Smith [22]
;
AOGC Consortium [57]
;
Albert V,Smith [82]
;
Kristin,Siggeirsdottir [83]
;
Tamara B,Harris [20]
;
M Carola,Zillikens [21]
;
Joyce B J,van Meurs [84]
;
Unnur,Thorsteinsdottir [85]
;
Matthew T,Maurano [22]
;
Nicholas J,Timpson [16]
;
Nicole,Soranzo [16]
;
Richard,Durbin [86]
;
Scott G,Wilson [87]
;
Evangelia E,Ntzani [5]
;
Matthew A,Brown [88]
;
Kari,Stefansson [10]
;
David A,Hinds [89]
;
Tim,Spector [90]
;
L Adrienne,Cupples [13]
;
Claes,Ohlsson [91]
;
Celia M T,Greenwood [92]
;
UK10K Consortium [78]
;
Rebecca D,Jackson [93]
;
David W,Rowe [43]
;
Cynthia A,Loomis [31]
;
David M,Evans [4]
;
Cheryl L,Ackert-Bicknell [94]
;
Alexandra L,Joyner [27]
;
Emma L,Duncan [30]
;
Douglas P,Kiel [95]
;
Fernando,Rivadeneira ;
J Brent,Richards
作者单位：
Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.;Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.
[1]
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.;Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.;Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.
[2]
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.;Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.;Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts 02114, USA.
[3]
Developmental Biology Program, Sloan Kettering Institute, New York, New York 10065, USA.
[4]
The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.
[5]
Department of Cell and Developmental Biology, Weill Cornell Medical College, New York, New York 10065, USA.;Tissue Engineering, Regeneration and Repair Program, Hospital for Special Surgery, New York 10021, USA.
[6]
Rheumatology Divison, Hospital for Special Surgery New York, New York 10021, USA.
[7]
School of Clinical Science, University of Bristol, Bristol BS10 5NB, UK.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
[8]
Fred Hutchinson Cancer Research Center, Seattle, Washington 98109, USA.
[9]
Department of Research, 23andMe, Mountain View, California 94041, USA.
[10]
Department of Population Genomics, deCODE Genetics, Reykjavik IS-101, Iceland.
[11]
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.
[12]
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden.
[13]
California Pacific Medical Center Research Institute, San Francisco, California 94158, USA.
[14]
Department of Public Health and Preventive Medicine, Oregon Health &Science University, Portland, Oregon 97239, USA.;Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.
[15]
Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge CB10 1SA, UK.
[16]
Departments of Pharmacology and Clinical Neurosciences, Umeå University, Umeå S-901 87, Sweden.;Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.
[17]
Centre for Bone and Arthritis Research, Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden.;Centre for Bone and Arthritis Research, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg S-413 45, Sweden.
[18]
McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada.
[19]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.
[20]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.
[21]
MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
[22]
Oregon Clinical and Translational Research Institute, Oregon Health &Science University, Portland, Oregon 97239, USA.;Department of Medical and Clinical Informatics, Oregon Health &Science University, Portland, Oregon 97239, USA.
[23]
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.;Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.
[24]
Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.
[25]
Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK.;Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
[26]
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.;Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.;Broad Institute of MIT and Harvard, Boston, Massachusetts 02115, USA.;Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts 02115, USA.
[27]
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.
[28]
McGill University and Genome Quebec Innovation Centre, Montréal H3A 0G1, Canada.;Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada.
[29]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands.
[30]
Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA.
[31]
Department of Biochemistry and Goodman Cancer Research Center, McGill University, Montréal H3G 1Y6, Canada.
[32]
Center for Musculoskeletal Research, University of Rochester, Rochester, New York 14642, USA.;Department of Computer Science, Trinity University, San Antonio, Texas 78212, USA.
[33]
Musculoskeletal Research Unit, University of Bristol, Bristol BS10 5NB, UK.
[34]
Department of Epidemiology, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands.
[35]
Department of Radiation Sciences, Umeå University, Umeå S-901 87, Sweden.
[36]
School of Public Health, University of Wisconsin, Milwaukee, Wisconsin 53726, USA.
[37]
School of Social and Community Medicine, University of Bristol, Bristol BS8 2BN, UK.
[38]
Department of Statistics, deCODE Genetics, Reykjavik IS-101, Iceland.
[39]
Department of Epidemiology and Biostatistics and the EMGO Institute for Health and Care Research, VU University Medical Center, Amsterdam 1007 MB, The Netherlands.
[40]
Department of Human Nutrition, Wageningen University, Wageningen 6700 EV, The Netherlands.
[41]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Department of Internal Medicine, Section Geriatrics, Academic Medical Center, Amsterdam 1105, The Netherlands.
[42]
The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.;MRC Integrative Epidemiology Unit, University of Bristol, Bristol BS8 2BN, UK.
[43]
Nordic Bioscience, Herlev 2730, Denmark.
[44]
Cordeliers Research Centre, INSERM UMRS 1138, Paris 75006, France.;Institute of Cardiometabolism and Nutrition, University Pierre &Marie Curie, Paris 75013, France.
[45]
Department of Internal Medicine, Erasmus Medical Center, Rotterdam 3015GE, The Netherlands.;Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden 2300RC, The Netherlands.
[46]
Departments of Medicine (Cardiovascular Medicine), Centre for Public Health Genomics, University of Virginia, Charlottesville, Virginia 22908, USA.
[47]
Department of Genetics, University of Barcelona, Barcelona 08028, Spain.;U-720, Centre for Biomedical Network Research on Rare Diseases (CIBERER), Barcelona 28029, Spain.;Department of Human Molecular Genetics, The Institute of Biomedicine of the University of Barcelona (IBUB), Barcelona 08028, Spain.
[48]
Women's Health Center of Excellence Family Medicine and Public Health, University of California - San Diego, San Diego, California 92093, USA.
[49]
Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA.;Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
[50]
Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02215, USA.
[51]
Osteoporosis &Bone Biology Program, Garvan Institute of Medical Research, Sydney 2010, Australia.;School of Medicine Sydney, University of Notre Dame Australia, Sydney 6959, Australia.;St. Vincent's Hospital &Clinical School, NSW University, Sydney 2010, Australia.
[52]
Osteoporosis &Bone Biology Program, Garvan Institute of Medical Research, Sydney 2010, Australia.;St. Vincent's Hospital &Clinical School, NSW University, Sydney 2010, Australia.
[53]
Musculoskeletal Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona 08003, Spain.;Cooperative Research Network on Aging and Fragility (RETICEF), Institute of Health Carlos III, 28029, Spain.;Department of Internal Medicine, Hospital del Mar, Universitat Autònoma de Barcelona, Barcelona 08193, Spain.
[54]
Musculoskeletal Research Group, Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona 08003, Spain.;Cooperative Research Network on Aging and Fragility (RETICEF), Institute of Health Carlos III, 28029, Spain.
[55]
Neuroepidemiology Section, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
[56]
Icelandic Heart Association, Kopavogur IS-201, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland.
[57]
Genetic epidemiology unit, Department of Epidemiology, Erasmus MC, Rotterdam 3000CA, The Netherlands.
[58]
Department of Orthopaedics, Skåne University Hospital Malmö 205 02, Sweden.
[59]
Department of Medical Sciences, University of Uppsala, Uppsala 751 85, Sweden.
[60]
Department of Surgical and Perioperative Sciences, Umeå Unviersity, Umeå 901 85, Sweden.
[61]
Department of Public Health and Clinical Medicine, Umeå University, Umeå SE-901 87, Sweden.
[62]
Department of Molecular Biology, Medical Biochemistry and Pathology, Université Laval, Québec City G1V 0A6, Canada.;Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU de Québec, Québec City G1V 4G2, Canada.
[63]
Axe Santé des Populations et Pratiques Optimales en Santé, Centre de recherche du CHU de Québec, Québec City G1V 4G2, Canada.
[64]
Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009, Australia.;Department of Medicine, University of Western Australia, Perth 6009, Australia.
[65]
Department of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus C 8000, Denmark.
[66]
Department of Endocrinology, Odense University Hospital, Odense C 5000, Denmark.
[67]
Department of Endocrinology, Hvidovre University Hospital, Hvidovre 2650, Denmark.
[68]
Farr Institute of Health Informatics Research, University College London, London NW1 2DA, UK.
[69]
Clinical Gerontology Unit, University of Cambridge, Cambridge CB2 2QQ, UK.
[70]
Medicine and Public Health and Primary Care, University of Cambridge, Cambridge CB1 8RN, UK.;Institute of Musculoskeletal Sciences, The Botnar Research Centre, University of Oxford, Oxford OX3 7LD, UK.
[71]
Department of Applied Biomedical Science, Faculty of Health Sciences, University of Malta, Msida MSD 2080, Malta.
[72]
Department of Orthopaedics, Skåne University Hospital Malmö 205 02, Sweden.;Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, 205 02, Sweden.
[73]
Clinical and Molecular Osteoporosis Research Unit, Department of Clinical Sciences Malmö, Lund University, 205 02, Sweden.
[74]
Department of Medicine and Psychiatry, University of Cantabria, Santander 39011, Spain.;Department of Internal Medicine, Hospital U.M. Valdecilla- IDIVAL, Santander 39008, Spain.
[75]
Department of Legal Medicine, University of Cantabria, Santander 39011, Spain.
[76]
Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, Western General Hospital, University of Edinburgh, Edinburgh EH4 2XU, UK.
[77]
Department of Reconstructive Sciences, College of Dental Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030, USA.
[78]
Department of Medicine and Physiology, McGill University, Montréal H4A 3J1, Canada.
[79]
Bone &Mineral Unit, Oregon Health &Science University, Portland, Oregon 97239, USA.;Department of Medicine, Oregon Health &Science University, Portland, Oregon 97239, USA.
[80]
Institute for Aging Research, Hebrew SeniorLife, Boston, Massachusetts 02131, USA.;Faculty of Medicine in the Galilee, Bar-Ilan University, Safed 13010, Israel.
[81]
Icelandic Heart Association, Kopavogur IS-201, Iceland.
[82]
Laboratory of Epidemiology, National Institute on Aging, National Institutes of Health, Bethesda, Maryland 20892, USA.
[83]
Department of Population Genomics, deCODE Genetics, Reykjavik IS-101, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland.
[84]
Department of Genome Sciences, University of Washington, Seattle, Washington 98195, USA.
[85]
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.;Department of Endocrinology and Diabetes, Sir Charles Gairdner Hospital, Nedlands 6009, Australia.;School of Medicine and Pharmacology, University of Western Australia, Crawley 6009, Australia.
[86]
Department of Hygiene and Epidemiology, University of Ioannina School of Medicine, Ioannina 45110, Greece.;Department of Health Services, Policy and Practice, Brown University School of Public Health, Providence, Rhode Island 02903, USA.
[87]
Faculty of Medicine, University of Iceland, Reykjavik IS-101, Iceland.;deCODE Genetics, Reykjavik IS-101, Iceland.
[88]
Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
[89]
Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA.;Framingham Heart Study, Framingham, Massachusetts 01702, USA.
[90]
Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.;Department of Human Genetics, McGill University, Montréal H3A 1B1, Canada.;Department of Epidemiology, Biostatistics and Occupational Health, McGill University, Montréal H3A 1A2, Canada.;Department of Oncology, Gerald Bronfman Centre, McGill University, Montréal H2W 1S6, Canada.
[91]
Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, The Ohio State University, Columbus, Ohio 43210, USA.
[92]
The Ronald O. Perelman Department of Dermatology and Department of Cell Biology, New York University School of Medicine, New York, New York 10016, USA.
[93]
The University of Queensland Diamantina Institute, Translational Research Institute, Princess Alexandra Hospital, Brisbane 4102, Australia.;Department of Diabetes and Endocrinology, Royal Brisbane and Women's Hospital, Brisbane 4029, Australia.
[94]
Departments of Medicine, Human Genetics, Epidemiology and Biostatistics, McGill University, Montréal H3A 1A2, Canada.;Department of Medicine, Lady Davis Institute for Medical Research, Jewish General Hospital, McGill University, Montréal H3T 1E2, Canada.;Department of Twin Research and Genetic Epidemiology, King's College London, London SE1 7EH, UK.
[95]
医学主题词
动物(Animals);骨密度(Bone Density);骨和骨组织(Bone and Bones);疾病模型, 动物(Disease Models, Animal);欧洲(Europe);女(雌)性(Female);骨折(Fractures, Bone);基因频率(Gene Frequency);疾病遗传易感性(Genetic Predisposition to Disease);遗传变异(Genetic Variation);基因组, 人(Genome, Human);基因组学(Genomics);基因型(Genotype);同源盒结构域蛋白质类(Homeodomain Proteins);人类(Humans);小鼠(Mice);序列分析, DNA(Sequence Analysis, DNA);Wnt蛋白质类(Wnt Proteins)
DOI
10.1038/nature14878
PMID
26367794
发布时间
2025-05-29
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Nature
Nature
112-7页
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