A novel locus in the oxidative stress-related gene ALOX12 moderates the association between PTSD and thickness of the prefrontal cortex.

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作者： Mark W,Miller ^[1] ; Erika J,Wolf ^[1] ; Naomi,Sadeh ^[1] ; Mark,Logue ^[2] ; Jeffrey M,Spielberg ^[3] ; Jasmeet P,Hayes ^[1] ; Emily,Sperbeck ^[4] ; Steven A,Schichman ^[5] ; Angie,Stone ^[5] ; Weleetka C,Carter ^[5] ; Donald E,Humphries ^[6] ; William,Milberg ^[7] ; Regina,McGlinchey ^[7]

作者单位： National Center for PTSD, Behavioral Science Division, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. ^[1] Research Service, VA Boston Healthcare System, Boston, MA, USA; Biomedical Genetics, Boston University School of Medicine, Boston, MA, USA; Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. ^[2] Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA; Neuroimaging Research for Veterans Center, VA Boston Healthcare System, Boston, MA, USA. ^[3] Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA. ^[4] Pharmacogenomics Analysis Laboratory, Research Service, Central Arkansas Veterans Healthcare System, Little Rock, AR, USA. ^[5] Massachusetts Veterans Epidemiology Research and Information Center, VA Boston Healthcare System, Boston, MA, USA. ^[6] Geriatric Research Educational and Clinical Center and Translational Research Center for TBI and Stress Disorders, VA Boston Healthcare System, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. ^[7]

关键词 ALOX12 Cortical thickness Factor analysis Genetic association analysis Oxidative stress Posttraumatic stress disorder