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Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR.

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第一作者： Francesco,Tres

第一单位： School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham NG7 2RD, UK. francesco.tres@nottingham.ac.uk.

作者： Francesco,Tres ^[1] ; Steven R,Coombes ^[2] ; Andrew R,Phillips ^[3] ; Leslie P,Hughes ^[4] ; Stephen A C,Wren ^[5] ; Jonathan W,Aylott ^[6] ; Jonathan C,Burley ^[7]

作者单位： School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham NG7 2RD, UK. francesco.tres@nottingham.ac.uk. ^[1] Pharmaceutical Development, AstraZeneca, Macclesfield SK10 2NA, UK. Steven.Coombes@astrazeneca.com. ^[2] Pharmaceutical Development, AstraZeneca, Macclesfield SK10 2NA, UK. andrew.r.phillips@astrazeneca.com. ^[3] Pharmaceutical Development, AstraZeneca, Macclesfield SK10 2NA, UK. Les.Hughes2@astrazeneca.com. ^[4] Pharmaceutical Development, AstraZeneca, Macclesfield SK10 2NA, UK. Stephen.Wren@astrazeneca.com. ^[5] School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham NG7 2RD, UK. Jon.Aylott@nottingham.ac.uk. ^[6] School of Pharmacy, Boots Science Building, University of Nottingham, Nottingham NG7 2RD, UK. jonathan.burley@nottingham.ac.uk. ^[7]

关键词 amorphous solid dispersions bicalutamide hot melt extrusion magnetic resonance imaging poorly soluble drugs solid-state transformations suppressed water 1H-NMR

医学主题词酰苯胺类(Anilides);化学, 药物(Chemistry, Pharmaceutical);药物调剂(Drug Compounding);药物稳定性(Drug Stability);磁共振成像(Magnetic Resonance Imaging);腈类(Nitriles);甲苯磺酰化合物(Tosyl Compounds)

DOI 10.3390/molecules200916404

PMID 26378506

发布时间 2020-02-25

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