The trimeric serine protease HtrA1 forms a cage-like inhibition complex with an anti-HtrA1 antibody.

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作者： Claudio,Ciferri ^[1] ; Michael T,Lipari ^[2] ; Wei-Ching,Liang ^[3] ; Alberto,Estevez ^[1] ; Julie,Hang ^[4] ; Scott,Stawicki ^[3] ; Yan,Wu ^[3] ; Paul,Moran ^[2] ; Mike,Elliott ^[4] ; Charles,Eigenbrot ^[1] ; Kenneth J,Katschke ^[5] ; Menno,van Lookeren Campagne ^[6] ; Daniel,Kirchhofer ^[7]

作者单位： Department of Structural Biology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. ^[1] Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. ^[2] Department of Antibody Engineering, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. ^[3] Department of Protein Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. ^[4] Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. ^[5] Department of Immunology, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. vanlookeren.menno@gene.com dak@gene.com. ^[6] Department of Early Discovery Biochemistry, Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, U.S.A. vanlookeren.menno@gene.com dak@gene.com. ^[7]

关键词 HtrA1 age-related macular degeneration antibody phage display serine protease