Tradeoff-based optimization criteria in clinical trials with multiple objectives and adaptive designs.

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作者： Alex,Dmitrienko ^[1] ; Gautier,Paux ^[2] ; Erik,Pulkstenis ^[3] ; Jianliang,Zhang ^[3]

作者单位： a Center for Statistics in Drug Development, Quintiles , Overland Park , Kansas , USA. ^[1] b Oncology Biostatistics, Institut de Recherches Internationales Servier (I.R.I.S.) , Suresnes , France. ^[2] c Biostatistics, MedImmune , Gaithersburg , Maryland , USA. ^[3]

关键词 Adaptive designs clinical scenario evaluation clinical trial optimization clinical trials multiple testing

主题词临床试验(主题)(Clinical Trials as Topic);数据说明, 统计(Data Interpretation, Statistical);目的(Goals);人类(Humans);研究设计(Research Design);样本大小(Sample Size)

DOI 10.1080/10543406.2015.1092032

PMID 26391238

发布时间 2016-12-30

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