Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts.
作者:
Tae-Hwi,Schwantes-An [1]
;
Juan,Zhang [2]
;
Li-Shiun,Chen [1]
;
Sarah M,Hartz [3]
;
Robert C,Culverhouse [4]
;
Xiangning,Chen [4]
;
Hilary,Coon [5]
;
Josef,Frank [6]
;
Helen M,Kamens [7]
;
Bettina,Konte [8]
;
Leena,Kovanen [9]
;
Antti,Latvala [10]
;
Lisa N,Legrand [11]
;
Brion S,Maher [12]
;
Whitney E,Melroy [13]
;
Elliot C,Nelson [14]
;
Mark W,Reid [15]
;
Jason D,Robinson [16]
;
Pei-Hong,Shen [9]
;
Bao-Zhu,Yang [10]
;
Judy A,Andrews [4]
;
Paul,Aveyard [17]
;
Olga,Beltcheva [18]
;
Sandra A,Brown [19]
;
Dale S,Cannon [20]
;
Sven,Cichon [17]
;
Robin P,Corley [21]
;
Norbert,Dahmen [22]
;
Louisa,Degenhardt [23]
;
Tatiana,Foroud [7]
;
Wolfgang,Gaebel [24]
;
Ina,Giegling [25]
;
Stephen J,Glatt [9]
;
Richard A,Grucza [26]
;
Jill,Hardin [27]
;
Annette M,Hartmann [28]
;
Andrew C,Heath [29]
;
Stefan,Herms [30]
;
Colin A,Hodgkinson [12]
;
Per,Hoffmann [31]
;
Hyman,Hops [4]
;
David,Huizinga [32]
;
Marcus,Ising [12]
;
Eric O,Johnson [4]
;
Elaine,Johnstone [24]
;
Radka P,Kaneva [25]
;
Kenneth S,Kendler [19]
;
Falk,Kiefer [24]
;
Henry R,Kranzler [25]
;
Ken S,Krauter [17]
;
Orna,Levran [33]
;
Susanne,Lucae [34]
;
Michael T,Lynskey [35]
;
Wolfgang,Maier [36]
;
Karl,Mann [22]
;
Nicholas G,Martin [6]
;
Manuel,Mattheisen [37]
;
Grant W,Montgomery [38]
;
Bertram,Müller-Myhsok [9]
;
Michael F,Murphy [39]
;
Michael C,Neale [40]
;
Momchil A,Nikolov [34]
;
Denise,Nishita [41]
;
Markus M,Nöthen [42]
;
John,Nurnberger [43]
;
Timo,Partonen [44]
;
Michele L,Pergadia [24]
;
Maureen,Reynolds [45]
;
Monika,Ridinger [46]
;
Richard J,Rose [44]
;
Noora,Rouvinen-Lagerström [34]
;
Norbert,Scherbaum [47]
;
Christine,Schmäl [6]
;
Michael,Soyka [4]
;
Michael C,Stallings [22]
;
Michael,Steffens [32]
;
Jens,Treutlein [24]
;
Ming,Tsuang [48]
;
Tamara L,Wall [13]
;
Norbert,Wodarz [4]
;
Vadim,Yuferov [49]
;
Peter,Zill [50]
;
Andrew W,Bergen [51]
;
Jingchun,Chen [52]
;
Paul M,Cinciripini [13]
;
Howard J,Edenberg [53]
;
Marissa A,Ehringer [43]
;
Robert E,Ferrell [54]
;
Joel,Gelernter [55]
;
David,Goldman [9]
;
John K,Hewitt [56]
;
Christian J,Hopfer [57]
;
William G,Iacono [8]
;
Jaakko,Kaprio [23]
;
Mary Jeanne,Kreek [23]
;
Ivo M,Kremensky [50]
;
Pamela A F,Madden [40]
;
Matt,McGue [58]
;
Marcus R,Munafò [32]
;
Robert A,Philibert [6]
;
Marcella,Rietschel [18]
;
Alec,Roy [59]
;
Dan,Rujescu [9]
;
Sirkku T,Saarikoski [10]
;
Gary E,Swan [60]
;
Alexandre A,Todorov [20]
;
Michael M,Vanyukov [61]
;
Robert B,Weiss [62]
;
Laura J,Bierut [19]
;
Nancy L,Saccone [9]
作者单位:
Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA.
[1]
Genometrics Section, Computational and Statistical Genomics Branch, Division of Intramural Research, National Human Genome Research Institute, US National Institutes of Health (NIH), Baltimore, MD, 21224, USA.
[2]
Key Laboratory of Brain Function and Disease, School of Life Sciences, Chinese Academy of Sciences, University of Science and Technology of China, Hefei, Anhui, 230026, China.
[3]
Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, 63110, USA.
[4]
Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, 63110, USA.
[5]
Department of Psychiatry, Virginia Institute for Psychiatric and Behavioral Genetics, Virginia Commonwealth University, Richmond, VA, 23298, USA.
[6]
Department of Psychiatry, University of Utah School of Medicine, Salt Lake City, UT, 84108, USA.
[7]
Department of Genetic Epidemiology in Psychiatry, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
[8]
Institute for Behavioral Genetics, University of Colorado, Boulder, CO, 80309, USA.
[9]
Department of Integrative Physiology, University of Colorado, Boulder, CO, 80309, USA.
[10]
Department of Biobehavioral Health, The Pennsylvania State University, University Park, PA, 16802, USA.
[11]
Department of Psychiatry, Universitätsklinikum Halle (Saale), 06112, Halle (Saale), Germany.
[12]
Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, 00271, Finland.
[13]
Department of Public Health, University of Helsinki, Helsinki, 00014, Finland.
[14]
Department of Psychology, University of Minnesota, Minneapolis, MN, 55455, USA.
[15]
Department of Mental Health, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, 21205, USA.
[16]
Oregon Research Institute, Eugene, OR, 97403, USA.
[17]
Department of Behavioral Science, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
[18]
Section of Human Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, 20892, USA.
[19]
Department of Psychiatry, Yale University, New Haven, CT, 06516, USA.
[20]
Department of Primary Care Health Sciences, University of Oxford, Oxford, OX2 6GG, United Kingdom.
[21]
Department of Medical Chemistry and Biochemistry, Molecular Medicine Center, Medical University-Sofia, 1431, Sofia, Bulgaria.
[22]
Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
[23]
Department. of Genomics, Life and Brain Center, Institute of Human Genetics, University of Bonn, Bonn, 53127, Germany.
[24]
Division of Medical Genetics, Department of Biomedicine, University Hospital Basel, University of Basel, Basel, 4003, Switzerland.
[25]
Ökumenisches Hainich-Klinikum, Mühlhausen/Thüringen, Germany.
[26]
National Drug and Alcohol Research Centre, University of New South Wales, Randwick, NSW, 2031, Australia.
[27]
School of Population and Global Health, University of Melbourne, Melbourne, 3010, Australia.
[28]
Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
[29]
University of Düsseldorf, 40225, Düsseldorf, Germany.
[30]
Department of Psychiatry and Behavioral Sciences, SUNY Upstate Medical University, Syracuse, NY, 13210, USA.
[31]
Center for Health Sciences, Biosciences Division, SRI International, Menlo Park, CA, 94025, USA.
[32]
Institute of Behavioral Science, University of Colorado, Boulder, CO, 80309, USA.
[33]
Max-Planck-Institute of Psychiatry, 80804, Munich, Germany.
[34]
Behavioral Health Research Division, Research Triangle Institute International, Durham, NC, 27709, USA.
[35]
Department of Oncology, University of Oxford, Oxford, OX3 7DQ, United Kingdom.
[36]
Department of Addictive Behavior and Addiction Medicine, Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
[37]
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
[38]
Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO, 80309, USA.
[39]
Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, 10065, USA.
[40]
Addictions Department, Institute of Psychiatry, King's College London, London, SE5 8BB, UK.
[41]
University of Bonn, 53113, Bonn, Germany.
[42]
Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, 68159, Mannheim, Germany.
[43]
Department of Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, 4029, Australia.
[44]
Harvard School of Public Health, Boston, MA, 02115, USA.
[45]
Aarhus University, Aarhus, 8000, Denmark.
[46]
Childhood Cancer Research Group, University of Oxford, Oxford, OX3 7LG, UK.
[47]
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
[48]
Department of Pharmaceutical Sciences, University of Pittsburgh, Pittsburgh, PA, 15213, USA.
[49]
Department of Psychiatry, University Medical Center Regensburg, University of Regensburg, 8548, Regensburg, Germany.
[50]
Psychiatric Hospital, Konigsfelden, Windisch, Switzerland.
[51]
Department of Psychological and Brain Sciences, Indiana University, Bloomington, IN, 47405, USA.
[52]
Addiction Research Group at the Department of Psychiatry and Psychotherapy, LVR Hospital Essen, University of Duisburg-Essen, 45147, Essen, Germany.
[53]
Department of Psychiatry, University of Munich, 3860, Munich, Germany.
[54]
Private Hospital Meiringen, Meiringen, Switzerland.
[55]
Department of Psychology & Neuroscience, University of Colorado, Boulder, CO, 80309, USA.
[56]
Research Department, Federal Institute for Drugs and Medical Devices (BfArM), Kurt-Georg-Kiesinger-Allee 3, 53175, Bonn, Germany.
[57]
University of Munich, Munich, Germany.
[58]
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
[59]
Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, 15261, USA.
[60]
Department of Genetics, Yale University, New Haven, CT, 06516, USA.
[61]
Department of Neurobiology, Yale University, New Haven, CT, 06516, USA.
[62]
Department of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, CO, 80045, USA.
[63]
Institute for Molecular Medicine FIMM, University of Helsinki, 00014, Helsinki, Finland.
[64]
MRC Integrative Epidemiology Unit, UK Centre for Tobacco and Alcohol Studies, and School of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK.
[65]
Department of Psychiatry, University of Iowa, Iowa City, IA, 52242, USA.
[66]
Psychiatry Service, Department of Veteran Affairs, New Jersey VA Health Care System, East Orange, NJ, 07018, USA.
[67]
Department of Medicine, Stanford Prevention Research Center, Stanford University School of Medicine, Stanford, CA, 94304, USA.
[68]
Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, UT, 84112, USA.
[69]
Department of Genetics, Washington University School of Medicine, 4523 Clayton Avenue, Campus Box 8232, St. Louis, MO, 63110, USA. nlims@genetics.wustl.edu.
[70]
主题词
青少年(Adolescent);成年人(Adult);等位基因(Alleles);病例对照研究(Case-Control Studies);儿童(Child);队列研究(Cohort Studies);基因频率(Gene Frequency);遗传关联研究(Genetic Association Studies);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);男(雄)性(Male);多态性, 单核苷酸(Polymorphism, Single Nucleotide);受体, 阿片样, μ(Receptors, Opioid, mu);样本大小(Sample Size);物质相关性障碍(Substance-Related Disorders)
DOI
10.1007/s10519-015-9737-3
PMID
26392368
发布时间
2024-06-15
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Behavior genetics
Behavior genetics
151-69页
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