A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts.-论文-万方医学网

第一作者： Meihua,Chen

第一单位： State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China.

作者： Meihua,Chen ^[1] ; Rong,Xiang ^[2] ; Yuan,Wen ^[1] ; Guangchao,Xu ^[1] ; Chunting,Wang ^[1] ; Shuntao,Luo ^[1] ; Tao,Yin ^[1] ; Xiawei,Wei ^[1] ; Bin,Shao ^[1] ; Ning,Liu ^[1] ; Fuchun,Guo ^[1] ; Meng,Li ^[1] ; Shuang,Zhang ^[1] ; Minmin,Li ^[1] ; Kexing,Ren ^[1] ; Yongsheng,Wang ^[1] ; Yuquan,Wei ^[1]

作者单位： State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu, China. ^[1] Department of Immunology, College of Medicine, Key Laboratory of Bioactive Materials, Ministry of Education, Nankai University, Tianjin, China. ^[2]

主题词动物(Animals);抗原, 肿瘤(Antigens, Neoplasm);抗肿瘤药(Antineoplastic Agents);CD8阳性T淋巴细胞(CD8-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);癌, Lewis肺(Carcinoma, Lewis Lung);细胞系, 肿瘤(Cell Line, Tumor);结肠肿瘤(Colonic Neoplasms);内肽酶类(Endopeptidases);成纤维细胞(Fibroblasts);明胶酶类(Gelatinases);免疫疗法(Immunotherapy);黑色素瘤, 实验性(Melanoma, Experimental);膜蛋白质类(Membrane Proteins);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 近交C57BL(Mice, Inbred C57BL);丝氨酸内肽酶类(Serine Endopeptidases);肿瘤微环境(Tumor Microenvironment);接种(Vaccination)

DOI 10.1038/srep14421

PMID 26394925

发布时间 2021-12-03

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A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts.

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A whole-cell tumor vaccine modified to express fibroblast activation protein induces antitumor immunity against both tumor cells and cancer-associated fibroblasts.

Scientific reports

相似文献

Scientific reports

相关期刊

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