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A genome-wide association study for colorectal cancer identifies a risk locus in 14q23.1.

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第一作者： Mathieu,Lemire

第一单位： Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.

作者： Mathieu,Lemire ^[1] ; Conghui,Qu ^[2] ; Lenora W M,Loo ^[3] ; Syed H E,Zaidi ^[1] ; Hansong,Wang ^[3] ; Sonja I,Berndt ^[4] ; Stéphane,Bézieau ^[5] ; Hermann,Brenner ^[6] ; Peter T,Campbell ^[7] ; Andrew T,Chan ^[8] ; Jenny,Chang-Claude ^[9] ; Mengmeng,Du ^[2] ; Christopher K,Edlund ^[10] ; Steven,Gallinger ^[11] ; Robert W,Haile ^[12] ; Tabitha A,Harrison ^[2] ; Michael,Hoffmeister ^[13] ; John L,Hopper ^[14] ; Lifang,Hou ^[15] ; Li,Hsu ^[16] ; Eric J,Jacobs ^[7] ; Mark A,Jenkins ^[14] ; Jihyoun,Jeon ^[2] ; Sébastien,Küry ^[17] ; Li,Li ^[18] ; Noralane M,Lindor ^[19] ; Polly A,Newcomb ^[20] ; John D,Potter ^[21] ; Gad,Rennert ^[22] ; Anja,Rudolph ^[9] ; Robert E,Schoen ^[23] ; Fredrick R,Schumacher ^[10] ; Daniela,Seminara ^[24] ; Gianluca,Severi ^[25] ; Martha L,Slattery ^[26] ; Emily,White ^[20] ; Michael O,Woods ^[27] ; Michelle,Cotterchio ^[28] ; Loic Le,Marchand ^[3] ; Graham,Casey ^[10] ; Steven B,Gruber ^[29] ; Ulrike,Peters ^[30] ; Thomas J,Hudson ^[31]

作者单位： Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada. ^[1] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington. ^[2] Epidemiology Program, University of Hawaii Cancer Center, Honolulu, Hawaii. ^[3] Occupational and Environmental Epidemiology Branch, National Cancer Institute, Bethesda, MD, USA. ^[4] Service de Génétique Médicale, CHU Nantes, Nantes, France.;EA 4273, Faculté de médecine, Université de Nantes, Nantes, France. ^[5] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.;German Cancer Consortium (DKTK), Heidelberg, Germany.;Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[6] American Cancer Society, Atlanta, GA, USA. ^[7] Division of Gastroenterology, Massachusetts General Hospital, Boston, MA, USA.;Channing Division of Network Medicine, Brigham and Women's Hospital, Boston, MA, USA. ^[8] Division of Cancer Epidemiology, Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[9] USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. ^[10] Samuel Lunenfeld Research Institute, Toronto, ON M5S 1X5, Canada.;Division of General Surgery, Toronto General Hospital, Toronto, ON M5G 2C4, Canada. ^[11] Department of Medicine, Division of Oncology, Stanford University, California, USA. ^[12] Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany. ^[13] Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia. ^[14] Department of Preventive Medicine and the Robert H. Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Illinois. ^[15] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.;Department of Biostatistics, University of Washington, Seattle, Washington. ^[16] Service de Génétique Médicale, CHU Nantes, Nantes, France. ^[17] Case Comprehensive Cancer Center and Swetland Center for Environmental Health, Case Western Reserve University, Cleveland, Ohio. ^[18] Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona. ^[19] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.;Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington. ^[20] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.;Department of Epidemiology, University of Washington School of Public Health, Seattle, Washington.;Centre for Public Health Research, Massey University, Wellington, New Zealand. ^[21] Department of Community Medicine and Epidemiology, Carmel Medical Center, Haifa, Israel.;Clalit Health Services National Cancer Control Center, Haifa, Israel.;Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel. ^[22] Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. ^[23] Division of Cancer Control and Population Sciences, National Cancer Institute, Bethesda, MD, USA. ^[24] Centre for Epidemiology and Biostatistics, School of Population and Global Health, The University of Melbourne, Melbourne, Australia.;Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.;Human Genetics Foundation (HuGeF), Torino, Italy. ^[25] Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City, UT, USA. ^[26] Discipline of Genetics, Memorial University of Newfoundland, St. John's, NF A1B 3V6, Canada. ^[27] Cancer Care Ontario, University of Toronto, Toronto, Ontario, Canada. ^[28] USC Norris Comprehensive Cancer Center, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.;USC Norris Comprehensive Cancer Center, Department of Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. ^[29] Public Health Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, Washington.;School of Public Health, University of Washington, Seattle, Washington. ^[30] Ontario Institute for Cancer Research, Toronto, ON M5G 0A3, Canada.;Department of Medical Biophysics, University of Toronto, Toronto, ON M5S 1A1, Canada.;Department of Molecular Genetics, University of Toronto, Toronto, ON M5S 1A1, Canada. ^[31]