FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance.-论文-万方医学网

作者： Gabriela,Nestal de Moraes ^[1] ; Deborah,Delbue ^[2] ; Karina L,Silva ^[3] ; Marcela Cristina,Robaina ^[2] ; Pasarat,Khongkow ^[4] ; Ana R,Gomes ^[4] ; Stefania,Zona ^[4] ; Susanne,Crocamo ^[5] ; André Luiz,Mencalha ^[6] ; Lídia M,Magalhães ^[7] ; Eric W-F,Lam ^[4] ; Raquel C,Maia ^[8]

作者单位： Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Praça da Cruz Vermelha, 23/6° andar, Centro, 20230-130 Rio de Janeiro, Brazil; Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM), Du Cane Road, London W12 0NN, UK. ^[1] Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Praça da Cruz Vermelha, 23/6° andar, Centro, 20230-130 Rio de Janeiro, Brazil. ^[2] Programa de Biologia Celular, INCA, Rua André Cavalcanti, 37/5° andar, Centro, 20231-050 Rio de Janeiro, Brazil. ^[3] Department of Surgery and Cancer, Imperial College London, Imperial Centre for Translational and Experimental Medicine (ICTEM), Du Cane Road, London W12 0NN, UK. ^[4] Núcleo de Pesquisa Clínica, Hospital de Câncer III, INCA, Rua Visconde de Santa Isabel, 274, Vila Isabel, 20560-120 Rio de Janeiro, Brazil. ^[5] Departamento de Biofísica e Biometria, Instituto de Biologia Roberto Alcântara Gomes, Universidade do Estado do Rio de Janeiro, Av. 28 de Setembro, 87 fundos, 4° andar, Vila Isabel, 20551-030 Rio de Janeiro, Brazil. ^[6] Divisão de Anatomia Patológica, INCA, Rua Cordeiro da Graça, 156, Santo Cristo, 20220-400 Rio de Janeiro, Brazil. ^[7] Laboratório de Hemato-Oncologia Celular e Molecular, Programa de Hemato-Oncologia Molecular, Instituto Nacional de Câncer (INCA), Praça da Cruz Vermelha, 23/6° andar, Centro, 20230-130 Rio de Janeiro, Brazil. Electronic address: rcmaia@inca.gov.br. ^[8]

主题词抗生素类, 抗肿瘤(Antibiotics, Antineoplastic);碱基序列(Base Sequence);结合部位(Binding Sites);乳腺肿瘤(Breast Neoplasms);细胞存活(Cell Survival);多柔比星(Doxorubicin);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);叉头转录因子类(Forkhead Transcription Factors);基因表达(Gene Expression);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);凋亡抑制蛋白质类(Inhibitor of Apoptosis Proteins);Kaplan-Meiers评估(Kaplan-Meier Estimate);中年人(Middle Aged);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);紫杉烷类(Taxoids);X连锁凋亡抑制蛋白质(X-Linked Inhibitor of Apoptosis Protein)

DOI 10.1016/j.cellsig.2015.09.013

PMID 26404623

发布时间 2021-10-06

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FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance.

Cellular signalling

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Cellular signalling

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FOXM1 targets XIAP and Survivin to modulate breast cancer survival and chemoresistance.

Cellular signalling

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Cellular signalling

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