Interferon-γ and Tumor Necrosis Factor-α Produced by T Cells Reduce the HBV Persistence Form, cccDNA, Without Cytolysis.

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作者： Yuchen,Xia ^[1] ; Daniela,Stadler ^[1] ; Julie,Lucifora ^[2] ; Florian,Reisinger ^[1] ; Dennis,Webb ^[3] ; Marianna,Hösel ^[4] ; Thomas,Michler ^[1] ; Karin,Wisskirchen ^[2] ; Xiaoming,Cheng ^[1] ; Ke,Zhang ^[1] ; Wen-Min,Chou ^[1] ; Jochen M,Wettengel ^[1] ; Antje,Malo ^[1] ; Felix,Bohne ^[1] ; Dieter,Hoffmann ^[1] ; Florian,Eyer ^[5] ; Robert,Thimme ^[6] ; Christine S,Falk ^[7] ; Wolfgang E,Thasler ^[8] ; Mathias,Heikenwalder ^[1] ; Ulrike,Protzer ^[9]

作者单位： Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany. ^[1] Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research, Munich and Hannover, Germany. ^[2] Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany. ^[3] Institute for Medical Microbiology, Immunology and Hygiene, University Hospital Cologne, Cologne, Germany; Center for Molecular Medicine Cologne, University Hospital Cologne, Cologne, Germany. ^[4] Medicine II, Department of Clinical Toxicology, University Hospital rechts der Isar of the Technical University of Munich, Munich, Germany. ^[5] Department of Medicine II, University Hospital Freiburg, Freiburg, Germany. ^[6] German Center for Infection Research, Munich and Hannover, Germany; Abt Transplantationsimmunologie, Medizinische Hochschule Hannover, Hannover, Germany. ^[7] Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Grosshadern Hospital, Ludwig Maximilians University, Munich, Germany. ^[8] Institute of Virology, Technische Universität München/Helmholtz Zentrum München, Munich, Germany; German Center for Infection Research, Munich and Hannover, Germany. Electronic address: protzer@tum.de. ^[9]

关键词 Apolipoprotein B mRNA Editing Enzyme HBV Persistence Immune Regulation T-Cell Receptor