T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.-论文-万方医学网

第一作者： Kevin D,Cook

第一单位： Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA.

作者： Kevin D,Cook ^[1] ; Karl B,Shpargel ^[2] ; Joshua,Starmer ^[2] ; Fatima,Whitfield-Larry ^[3] ; Bridget,Conley ^[4] ; Denise E,Allard ^[5] ; Julia E,Rager ^[6] ; Rebecca C,Fry ^[6] ; Marsha L,Davenport ^[4] ; Terry,Magnuson ^[2] ; Jason K,Whitmire ^[7] ; Maureen A,Su ^[8]

作者单位： Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[1] Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Carolina Center for Genome Sciences, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[2] Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[3] Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[4] Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[5] Department of Environmental Sciences and Engineering, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. ^[6] Department of Genetics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address: jwhitmir@email.unc.edu. ^[7] Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Department of Pediatrics, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA; Department of Microbiology and Immunology, University of North Carolina at Chapel Hill School of Medicine, 120 Mason Farm Road, Chapel Hill, NC 27599, USA. Electronic address: masu@email.unc.edu. ^[8]

主题词动物(Animals);抗体, 病毒(Antibodies, Viral);细胞分化(Cell Differentiation);女(雌)性(Female);基因剂量(Gene Dosage);基因表达调控(Gene Expression Regulation);疾病遗传易感性(Genetic Predisposition to Disease);组蛋白脱甲基酶类(Histone Demethylases);组蛋白类(Histones);人类(Humans);免疫记忆(Immunologic Memory);白细胞介素6受体α亚单位(Interleukin-6 Receptor alpha Subunit);淋巴细胞协同作用(Lymphocyte Cooperation);淋巴细胞性脉络丛脑膜炎(Lymphocytic Choriomeningitis);淋巴细胞性脉络丛脑膜炎病毒(Lymphocytic choriomeningitis virus);甲基化(Methylation);小鼠(Mice);模型, 免疫学(Models, Immunological);核蛋白质类(Nuclear Proteins);中耳炎(Otitis Media);蛋白质加工, 转译后(Protein Processing, Post-Translational);受体, CXCR5(Receptors, CXCR5);种特异性(Species Specificity);T淋巴细胞亚群(T-Lymphocyte Subsets);T淋巴细胞, 辅助诱导(T-Lymphocytes, Helper-Inducer);转录, 遗传(Transcription, Genetic);特纳综合征(Turner Syndrome);病毒血症(Viremia);毒力(Virulence);X染色体失活(X Chromosome Inactivation)

DOI 10.1016/j.immuni.2015.09.002

PMID 26431949

发布时间 2019-12-10

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T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.

Immunity

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T Follicular Helper Cell-Dependent Clearance of a Persistent Virus Infection Requires T Cell Expression of the Histone Demethylase UTX.

Immunity

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