Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.-论文-万方医学网

作者： Emily J,Colbeck ^[1] ; James P,Hindley ^[1] ; Kathryn,Smart ^[1] ; Emma,Jones ^[1] ; Anja,Bloom ^[1] ; Hayley,Bridgeman ^[1] ; Rhoanne C,McPherson ^[2] ; Darryl G,Turner ^[2] ; Kristin,Ladell ^[1] ; David A,Price ^[1] ; Richard A,O'Connor ^[2] ; Stephen M,Anderton ^[2] ; Andrew J,Godkin ^[1] ; Awen M,Gallimore ^[1]

作者单位： Institute of Infection Immunity and Biochemistry, Cardiff University School of Medicine, Cardiff, CF14 4XN, UK. ^[1] MRC Centre for Inflammation Research, Centre for Multiple Sclerosis Research and Centre for Immunity Infection and Evolution, University of Edinburgh, Edinburgh EH16 4TJ, UK. ^[2]

主题词动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);细胞增殖(Cell Proliferation);细胞, 培养的(Cells, Cultured);纤维肉瘤(Fibrosarcoma);叉头转录因子类(Forkhead Transcription Factors);炎症介导素类(Inflammation Mediators);白细胞介素2(Interleukin-2);淋巴细胞活化(Lymphocyte Activation);淋巴细胞, 肿瘤浸润(Lymphocytes, Tumor-Infiltrating);甲基胆蒽(Methylcholanthrene);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);表型(Phenotype);肉瘤, 实验性(Sarcoma, Experimental);信号传导(Signal Transduction);T盒域蛋白质类(T-Box Domain Proteins);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);Th1细胞(Th1 Cells);肿瘤微环境(Tumor Microenvironment)

DOI 10.18632/oncotarget.5584

PMID 26433463

发布时间 2022-01-29

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Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

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Eliminating roles for T-bet and IL-2 but revealing superior activation and proliferation as mechanisms underpinning dominance of regulatory T cells in tumors.

Oncotarget

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Oncotarget

相关期刊

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