Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.

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作者： Adam,Kinnaird ^[1] ; Peter,Dromparis ^[2] ; Bruno,Saleme ^[2] ; Vikram,Gurtu ^[2] ; Kristalee,Watson ^[3] ; Roxane,Paulin ^[2] ; Sotirios,Zervopoulos ^[2] ; Trevor,Stenson ^[2] ; Gopinath,Sutendra ^[2] ; Desmond B,Pink ^[4] ; Katia,Carmine-Simmen ^[4] ; Ronald,Moore ^[5] ; John D,Lewis ^[4] ; Evangelos D,Michelakis ^[6]

作者单位： Division of Urology, University of Alberta, Edmonton, Alberta, Canada; Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. ^[1] Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. ^[2] Department of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta, Canada. ^[3] Department of Oncology, University of Alberta, Edmonton, Alberta, Canada. ^[4] Division of Urology, University of Alberta, Edmonton, Alberta, Canada. ^[5] Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. Electronic address: em2@ualberta.ca. ^[6]

关键词 Dichloroacetate Metabolic modulation Pyruvate dehydrogenase kinase Warburg effect