A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

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作者： Melissa A,Pinard ^[1] ; Mayank,Aggarwal ^[2] ; Brian P,Mahon ^[1] ; Chingkuang,Tu ^[3] ; Robert,McKenna ^[1]

作者单位： Department of Biochemistry and Molecular Biology, College of Medicine, University of Florida, Gainesville, FL 32610, USA. ^[1] Division of Biology and Soft Matter, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA. ^[2] Department of Pharmacology, College of Medicine, University of Florida, Gainesville, FL 32610, USA. ^[3]

关键词 CA IX mimic carbonic anhydrase IX isoform-specific drug design sucrose sugar approach α-carbonic anhydrase

主题词抗原, 肿瘤(Antigens, Neoplasm);结合部位(Binding Sites);碳酸酐酶抑制剂(Carbonic Anhydrase Inhibitors);碳酸酐酶类(Carbonic Anhydrases);结晶(Crystallization);结晶学, X线(Crystallography, X-Ray);荧光计(Fluorometry);人类(Humans);同工酶类(Isoenzymes);动力学(Kinetics);肿瘤(Neoplasms);蔗糖(Sucrose)

DOI 10.1107/S2053230X1501239X

PMID 26457530

发布时间 2024-05-20

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Acta crystallographica. Section F, Structural biology communications

2015年71卷Pt 10期

1352-8页

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A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

Acta crystallographica. Section F, Structural biology communications

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Acta crystallographica. Section F, Structural biology communications

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A sucrose-binding site provides a lead towards an isoform-specific inhibitor of the cancer-associated enzyme carbonic anhydrase IX.

Acta crystallographica. Section F, Structural biology communications

相似文献

Acta crystallographica. Section F, Structural biology communications

相关期刊

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