New Non-Toxic Semi-Synthetic Derivatives from Natural Diterpenes Displaying Anti-Tuberculosis Activity.

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作者： Priscilla M,Matos ^[1] ; Brian,Mahoney ^[2] ; Yohan,Chan ^[3] ; David P,Day ^[4] ; Mirela M W,Cabral ^[5] ; Carlos H G,Martins ^[6] ; Raquel A,Santos ^[7] ; Jairo K,Bastos ^[8] ; Philip C Bulman,Page ^[9] ; Vladimir C G,Heleno ^[10]

作者单位： Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca 14404-600, Brazil. pcxpm1@nottingham.ac.uk. ^[1] School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. mahoneybri@gmail.com. ^[2] School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. y.chan@uea.ac.uk. ^[3] School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. ddukbr@gmail.com. ^[4] Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca 14404-600, Brazil. mirela@com4.com.br. ^[5] Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca 14404-600, Brazil. carlos.martins@unifran.edu.br. ^[6] Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca 14404-600, Brazil. raquel.santos@unifran.edu.br. ^[7] Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto 14040-903, Brazil. jkbastos@fcfrp.usp.br. ^[8] School of Chemistry, University of East Anglia, Norwich Research Park, Norwich, NR4 7TJ, UK. p.page@uea.ac.uk. ^[9] Pesquisas em Ciências Exatas e Tecnológicas, Universidade de Franca, Franca 14404-600, Brazil. vladimir.heleno@unifran.edu.br. ^[10]

关键词 Mycobacterium tuberculosis anti-tuberculosis activity copalic acid cytotoxicity diterpene derivatives kaurenoic acid structural modification

主题词抗结核药(Antitubercular Agents);生物制品(Biological Products);二萜类(Diterpenes);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);结核分枝杆菌(Mycobacterium tuberculosis);构效关系(Structure-Activity Relationship)

DOI 10.3390/molecules201018264

PMID 26457701

发布时间 2020-02-25

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