Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.-论文-万方医学网

作者： Cristina,Talarico ^[1] ; Lucia,D'Antona ^[1] ; Domenica,Scumaci ^[2] ; Agnese,Barone ^[2] ; Francesco,Gigliotti ^[1] ; Claudia Vincenza,Fiumara ^[2] ; Vincenzo,Dattilo ^[1] ; Enzo,Gallo ^[3] ; Paolo,Visca ^[3] ; Francesco,Ortuso ^[1] ; Claudia,Abbruzzese ^[4] ; Lorenzo,Botta ^[5] ; Silvia,Schenone ^[6] ; Giovanni,Cuda ^[2] ; Stefano,Alcaro ^[1] ; Cataldo,Bianco ^[2] ; Patrizia,Lavia ^[7] ; Marco G,Paggi ^[4] ; Nicola,Perrotti ^[1] ; Rosario,Amato ^[1]

作者单位： Department of "Scienze della Salute", University "Magna Graecia" of Catanzaro, Viale Europa, Catanzaro, Italy. ^[1] Department of "Medicina Sperimentale e Clinica", University "Magna Graecia" of Catanzaro, Viale Europa, Catanzaro, Italy. ^[2] Section of Pathology, Regina Elena National Cancer Institute, IRCCS, Rome, Italy. ^[3] Experimental Oncology, Regina Elena National Cancer Institute, IRCCS, Rome, Italy. ^[4] Department of Biotecnologie, Chimica e Farmacia, University of Siena, Siena, Italy. ^[5] Department of Farmacia, University of Genova, Genova, Italy. ^[6] Institute of Molecular Biology and Pathology (IBPM), National Research Council of Italy (CNR), c/o University "La Sapienza", Rome, Italy. ^[7]

主题词动物(Animals);细胞凋亡(Apoptosis);印迹法, 蛋白质(Blotting, Western);癌, 肝细胞(Carcinoma, Hepatocellular);细胞周期(Cell Cycle);细胞增殖(Cell Proliferation);女(雌)性(Female);γ射线(Gamma Rays);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);即早蛋白质类(Immediate-Early Proteins);免疫酶技术(Immunoenzyme Techniques);肝肿瘤(Liver Neoplasms);小鼠(Mice);小鼠, 近交NOD(Mice, Inbred NOD);小鼠, SCID(Mice, SCID);蛋白质组(Proteome);吡唑类(Pyrazoles);嘧啶类(Pyrimidines);辐射耐受性(Radiation Tolerance);肿瘤细胞, 培养的(Tumor Cells, Cultured);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)

DOI 10.18632/oncotarget.5527

PMID 26462020

发布时间 2021-12-03

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Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.

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Preclinical model in HCC: the SGK1 kinase inhibitor SI113 blocks tumor progression in vitro and in vivo and synergizes with radiotherapy.

Oncotarget

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Oncotarget

相关期刊

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