LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking

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第一作者： Daisuke,Tanokashira

第一单位： Department of Demyelinating Disease and Aging, National Institute of Neuroscience , NCNP, Kodaira, Tokyo 187-8502, Japan.

作者： Daisuke,Tanokashira ^[1] ; Kazumi,Motoki ^[1] ; Seiji,Minegishi ^[1] ; Ai,Hosaka ^[2] ; Naomi,Mamada ^[2] ; Akira,Tamaoka ^[3] ; Takashi,Okada ^[4] ; Madepalli K,Lakshmana ^[5] ; Wataru,Araki ^[1]

作者单位： Department of Demyelinating Disease and Aging, National Institute of Neuroscience , NCNP, Kodaira, Tokyo 187-8502, Japan. ^[1] Department of Demyelinating Disease and Aging, National Institute of Neuroscience , NCNP, Kodaira, Tokyo 187-8502, Japan ; Department of Neurology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki 305-8575, Japan. ^[2] Department of Neurology, Faculty of Medicine, University of Tsukuba , Tsukuba, Ibaraki 305-8575, Japan. ^[3] Department of Biochemistry and Molecular Biology, Nippon Medical School , Bunkyo-ku, Tokyo 113-8602, Japan. ^[4] Torrey Pines Institute for Molecular Studies , Port St. Lucie, Florida 34987-2352. ^[5]

关键词 Alzheimer’s disease BACE1 LRP1 amyloid beta-protein neuron

DOI 10.1523/ENEURO.0006-15.2015

PMID 26464978

发布时间 2018-11-13

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LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking

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LRP1 Downregulates the Alzheimer's β-Secretase BACE1 by Modulating Its Intraneuronal Trafficking

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