Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice.-论文-万方医学网

作者： Sangmi,Ock ^[1] ; Wang Soo,Lee ^[1] ; Jihyun,Ahn ^[1] ; Hyun Min,Kim ^[1] ; Hyun,Kang ^[1] ; Ho-Shik,Kim ^[1] ; Daewoong,Jo ^[1] ; E Dale,Abel ^[1] ; Tae Jin,Lee ^[1] ; Jaetaek,Kim ^[1]

作者单位： Division of Endocrinology and Metabolism (S.O., J.A., H.M.K., J.K.), Department of Internal Medicine, Division of Cardiology (W.S.L.), Department of Internal Medicine, and Departments of Anesthesiology (H.K.) and Pathology (T.J.L.), College of Medicine, Chung-Ang University, Seoul, 156-755, Korea; Department of Biochemistry (H.-S.K.), College of Medicine, The Catholic University of Korea, Seoul, 110-758, Korea; Department of Surgery (D.J.), Vanderbilt University School of Medicine, Nashville, Tennessee 37232; and Fraternal Order of Eagles Diabetes Research Center and Division of Endocrinology and Metabolism (D.A.), University of Iowa Carver College of Medicine, Iowa City, Iowa 52242. ^[1]

主题词衰老(Aging);动物(Animals);心脏扩大(Cardiomegaly);细胞, 培养的(Cells, Cultured);细胞因子类(Cytokines);酶抑制剂(Enzyme Inhibitors);纤维化(Fibrosis);基因表达调控, 发育期(Gene Expression Regulation, Developmental);心室(Heart Ventricles);胰岛素样生长因子Ⅰ(Insulin-Like Growth Factor I);男(雄)性(Male);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);肌细胞, 心脏(Myocytes, Cardiac);磷酸肌醇3-激酶(Phosphatidylinositol 3-Kinase);磷酰化(Phosphorylation);蛋白质加工, 转译后(Protein Processing, Post-Translational);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);受体, IGF1型(Receptor, IGF Type 1);信号传导(Signal Transduction);心室重构(Ventricular Remodeling)

DOI 10.1210/en.2015-1709

PMID 26469138

发布时间 2019-12-10

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Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice.

Endocrinology

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Endocrinology

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Deletion of IGF-1 Receptors in Cardiomyocytes Attenuates Cardiac Aging in Male Mice.

Endocrinology

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Endocrinology

相关期刊

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