The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.

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作者： Manando,Nakasaki ^[1] ; Yongsung,Hwang ^[2] ; Yun,Xie ^[2] ; Sunny,Kataria ^[2] ; Rupali,Gund ^[1] ; Edries Y,Hajam ^[1] ; Rekha,Samuel ^[1] ; Renu,George ^[3] ; Debashish,Danda ^[4] ; Paul,M J ^[5] ; Tomoyuki,Nakamura ^[6] ; Zhouxin,Shen ^[7] ; Steve,Briggs ^[8] ; Shyni,Varghese ^[8] ; Colin,Jamora ^[2]

作者单位： IFOM-inSTEM Joint Research Laboratory, Centre for Inflammation and Tissue Homeostasis (inStem), NCBS GKVK Post, Bellary Road, Bangalore 560065, India. ^[1] Department of Bioengineering, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0695, USA. ^[2] Center for Stem Cell Research, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India. ^[3] Department of Dermatology, Venereology and Leprosy, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India. ^[4] Department of Rheumatology, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India. ^[5] Department of Surgery, Christian Medical College, Ida Scudder Road, Vellore, Tamil Nadu 632004, India. ^[6] Department of Pharmacology, Kansai Medical University, 10-15 Fumizono-cho, Moriguchi, Osaka 570-8506, Japan. ^[7] Section of Cell and Developmental Biology, Division of Biological Sciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, California 92093-0380, USA. ^[8]

主题词成年人(Adult);动物(Animals);动物, 新生(Animals, Newborn);炎症趋化因子类(Chemokines);细胞外基质(Extracellular Matrix);细胞外基质蛋白质类(Extracellular Matrix Proteins);女(雌)性(Female);成纤维细胞(Fibroblasts);纤维化(Fibrosis);人类(Humans);炎症(Inflammation);男(雄)性(Male);小鼠, 转基因(Mice, Transgenic);中年人(Middle Aged);表型(Phenotype);重组蛋白质类(Recombinant Proteins);皮肤(Skin);转录因子(Transcription Factors)

DOI 10.1038/ncomms9574

PMID 26469761

发布时间 2019-04-20

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Nature communications

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The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.

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The matrix protein Fibulin-5 is at the interface of tissue stiffness and inflammation in fibrosis.

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