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Re-engineering a neuroprotective, clinical drug as a procognitive agent with high in vivo potency and with GABAA potentiating activity for use in dementia.

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作者单位: Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. jialuo@uic.edu. [1] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. suelee1@uic.edu. [2] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. lvandev2@uic.edu. [3] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. qinzhh@uic.edu. [4] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. spiyan2@uic.edu. [5] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. etavas2@uic.edu. [6] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. rasgho2@uic.edu. [7] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. benaissa@uic.edu. [8] Department of Pathology and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St., New York, NY, 10032, USA. mf2257@columbia.edu. [9] Department of Pathology and The Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, 630 W 168th St., New York, NY, 10032, USA. oa1@columbia.edu. [10] Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Lions of Illinois Eye Research Institute, University of Illinois at Chicago, 1855 W. Taylor St., Chicago, IL, 60612, USA. lyue@usc.edu. [11] Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St., Chicago, IL, 60607, USA. lyue@usc.edu. [12] Department of Ophthalmology, University of Southern California, 1441 Eastlake Ave., Los Angeles, CA, 90033, USA. lyue@usc.edu. [13] Department of Ophthalmology and Visual Sciences, Illinois Eye and Ear Infirmary, Lions of Illinois Eye Research Institute, University of Illinois at Chicago, 1855 W. Taylor St., Chicago, IL, 60612, USA. davipepp@uic.edu. [14] Department of Bioengineering, University of Illinois at Chicago, 851 S. Morgan St., Chicago, IL, 60607, USA. davipepp@uic.edu. [15] Department of Medicinal Chemistry and Pharmacognosy, University of Illinois College of Pharmacy, UIC, 833 S. Wood St., Chicago, IL, 60612-7231, USA. thatcher@uic.edu. [16]
DOI 10.1186/s12868-015-0208-9
PMID 26480871
发布时间 2018-11-13
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