首页> Brain : a journal of neurology> Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

Olesoxime suppresses calpain activation and mutant huntingtin fragmentation in the BACHD rat.

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第一作者： Laura E,Clemens

第一单位： 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany.

作者： Laura E,Clemens ^[1] ; Jonasz J,Weber ^[1] ; Tanja T,Wlodkowski ^[1] ; Libo,Yu-Taeger ^[1] ; Magali,Michaud ^[2] ; Carsten,Calaminus ^[3] ; Schamim H,Eckert ^[4] ; Janett,Gaca ^[4] ; Andreas,Weiss ^[5] ; Janine C D,Magg ^[1] ; Erik K H,Jansson ^[1] ; Gunter P,Eckert ^[4] ; Bernd J,Pichler ^[3] ; Thierry,Bordet ^[2] ; Rebecca M,Pruss ^[2] ; Olaf,Riess ^[1] ; Huu P,Nguyen ^[6]

作者单位： 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany. ^[1] 3 Trophos SA., Parc Scientifique de Luminy Case 931, 13288 Marseille Cedex 9, France. ^[2] 4 Werner Siemens Imaging Center, Department of Preclinical Imaging and Radiopharmacy, University of Tuebingen, Roentgenweg 13, 72076 Tuebingen, Germany. ^[3] 5 Department of Pharmacology, Goethe University Frankfurt am Main, Max-von-Laue Str. 9, 60438 Frankfurt, Germany. ^[4] 6 Novartis Institutes for BioMedical Research, Klybeckstrasse 141, 4057 Basel, Switzerland. ^[5] 1 Institute of Medical Genetics and Applied Genomics, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany 2 Centre for Rare Diseases, University of Tuebingen, Calwerstrasse 7, 72076 Tuebingen, Germany hoa.nguyen@med.uni-tuebingen.de. ^[6]

关键词 Huntington’s disease calpain mitochondrial dysfunction mutant huntingtin aggregates olesoxime