Oxidative DNA damage in mouse sperm chromosomes: Size matters.

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作者： Ayhan,Kocer ^[1] ; Joelle,Henry-Berger ^[1] ; Anais,Noblanc ^[1] ; Alexandre,Champroux ^[1] ; Romain,Pogorelcnik ^[1] ; Rachel,Guiton ^[1] ; Laurent,Janny ^[2] ; Hanae,Pons-Rejraji ^[2] ; Fabrice,Saez ^[1] ; Graham D,Johnson ^[3] ; Stephen A,Krawetz ^[3] ; Juan G,Alvarez ^[4] ; R John,Aitken ^[5] ; Joël R,Drevet ^[6]

作者单位： GReD laboratory, CNRS UMR6293-INSERM U1103-Clermont Université, BP80006, 63171 Aubière cedex, France. ^[1] GReD laboratory, CNRS UMR6293-INSERM U1103-Clermont Université, BP80006, 63171 Aubière cedex, France; CHU Estaing, Assistance Médicale à la Procréation, Clermont-Ferrand, France. ^[2] Center for Molecular Medicine & Genetics, Department of Obstetrics & Gynecology, Wayne State University, Detroit, MI 48201, USA. ^[3] Centro ANDROGEN, La Coruña, Spain; Harvard Medical School, Boston, MA 02115, USA. ^[4] Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, Australia. ^[5] GReD laboratory, CNRS UMR6293-INSERM U1103-Clermont Université, BP80006, 63171 Aubière cedex, France. Electronic address: joel.drevet@univ-bpclermont.fr. ^[6]

关键词 8-Hydroxy-2′-deoxyguanosine (8-OHdG)Mutational risk Nuclear organization Oxidative stress Sperm DNA integrity