首页> Journal of pharmaceutical and biomedical analysis> Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

Development and validation of an enantioselective LC-MS/MS method for the analysis of the anthelmintic drug praziquantel and its main metabolite in human plasma, blood and dried blood spots.

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第一作者： Isabel,Meister

第一单位： Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland.

作者： Isabel,Meister ^[1] ; Anna,Leonidova ^[1] ; Jana,Kovač ^[1] ; Urs,Duthaler ^[1] ; Jennifer,Keiser ^[2] ; Jörg,Huwyler ^[3]

作者单位： Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland. ^[1] Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel, Switzerland; University of Basel, P.O. Box, CH-4003 Basel, Switzerland. Electronic address: jennifer.keiser@unibas.ch. ^[2] Department of Pharmaceutical Sciences, Division of Pharmaceutical Technology, University of Basel, Klingelbergstrasse 50, CH-4056 Basel, Switzerland. ^[3]

关键词 Dried blood spot Enantiomer LC–MS/MS Pharmacokinetics Praziquantel R-trans-4-OH-PZQ

医学主题词抗蠕虫药(Anthelmintics);色谱法, 液相(Chromatography, Liquid);人类(Humans);吡喹酮(Praziquantel);结果可重复性(Reproducibility of Results);立体异构现象(Stereoisomerism);串联质谱法(Tandem Mass Spectrometry)

DOI 10.1016/j.jpba.2015.10.011

PMID 26517852

发布时间 2017-09-26

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