Development of a potent and selective cell penetrant Legumain inhibitor.

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作者： Kerry A,Ness ^[1] ; Sharon L,Eddie ^[1] ; Catherine A,Higgins ^[1] ; Amy,Templeman ^[1] ; Zenobia,D'Costa ^[1] ; Kishore K D,Gaddale ^[1] ; Samira,Bouzzaoui ^[1] ; Linda,Jordan ^[2] ; Dominic,Janssen ^[2] ; Timothy,Harrison ^[2] ; Frank,Burkamp ^[2] ; Andrew,Young ^[3] ; Roberta,Burden ^[3] ; Christopher J,Scott ^[3] ; Paul B,Mullan ^[1] ; Rich,Williams ^[4]

作者单位： CCRCB Drug Discovery Group, Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd., Belfast BT9 7BL, UK. ^[1] Almac Discovery, Almac House, 20 Seagoe Industrial Estate, Craigavon BT63 5QD, UK. ^[2] School of Pharmacy, Queen's University Belfast, 97 Lisburn Rd., Belfast BT9 7BL, UK. ^[3] CCRCB Drug Discovery Group, Centre for Cancer Research and Cell Biology, Queen's University Belfast, 97 Lisburn Rd., Belfast BT9 7BL, UK. Electronic address: rich.williams@qub.ac.uk. ^[4]

关键词 Cancer Cellular active inhibitor Cyano warhead Legumain

主题词细胞存活(Cell Survival);半胱氨酸内肽酶类(Cysteine Endopeptidases);酶抑制剂(Enzyme Inhibitors);半数抑制浓度(Inhibitory Concentration 50);分子结构(Molecular Structure)

DOI 10.1016/j.bmcl.2015.10.001

PMID 26522952

发布时间 2016-12-30

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