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Inter-laboratory study of human in vitro toxicogenomics-based tests as alternative methods for evaluating chemical carcinogenicity: a bioinformatics perspective.

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第一作者： R,Herwig

第一单位： Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 73, 14195, Berlin, Germany. herwig@molgen.mpg.de.

作者： R,Herwig ^[1] ; H,Gmuender ^[2] ; R,Corvi ^[3] ; K M,Bloch ^[4] ; A,Brandenburg ^[2] ; J,Castell ^[5] ; L,Ceelen ^[6] ; C,Chesne ^[7] ; T Y,Doktorova ^[6] ; D,Jennen ^[8] ; P,Jennings ^[9] ; A,Limonciel ^[9] ; E A,Lock ^[4] ; T,McMorrow ^[10] ; P,Phrakonkham ^[3] ; R,Radford ^[10] ; C,Slattery ^[10] ; R,Stierum ^[11] ; M,Vilardell ^[12] ; T,Wittenberger ^[2] ; R,Yildirimman ^[12] ; M,Ryan ^[10] ; V,Rogiers ^[6] ; J,Kleinjans ^[8]

作者单位： Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 73, 14195, Berlin, Germany. herwig@molgen.mpg.de. ^[1] Genedata AG, Margarethenstrasse 38, 4053, Basel, Switzerland. ^[2] European Union Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM), Institute for Health and Consumer Protection (IHCP), European Commission Joint Research Centre, TP 126, Via E. Fermi 2749, 21027, Ispra, Italy. ^[3] School of Pharmacy and Biomolecular Sciences, Liverpool John Moores University, Byrom Street, Liverpool, L3 3AF, UK. ^[4] Department of Biochemistry and Molecular Biology, Faculty of Medicine, University of Valencia, Av. Blasco Ibanez 15, 46010, Valencia, Spain. ^[5] Department of In Vitro Toxicology and Dermato-Cosmetology, Vrije Universiteit Brussel, Laarbeeklaan 103, 1090, Brussels, Belgium. ^[6] Biopredic International, Parc d'affaires de la Bretèche, Bldg. A4, 35760, St Gregoire, France. ^[7] Department of Toxicogenomics, Maastricht University, Maastricht, The Netherlands. ^[8] Division of Physiology, Department of Physiology and Medical Physics, Medical University of Innsbruck, Innsbruck, Austria. ^[9] Conway Institute, School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland. ^[10] Department of Risk Analysis for Products in Development, Netherlands Organisation for Applied Scientific Research (TNO), Utrechtseweg 48, 3704 HE, Zeist, The Netherlands. ^[11] Department Computational Molecular Biology, Max-Planck-Institute for Molecular Genetics, Ihnestr. 73, 14195, Berlin, Germany. ^[12]

关键词 Bioinformatics Carcinogenicity In vitro assays Inter-laboratory assessment Pre-validation Toxicogenomics