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Novel orally active inhibitors of β-1,3-glucan synthesis derived from enfumafungin.

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第一作者： James M,Apgar

第一单位： Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: james_apgar@merck.com.

作者： James M,Apgar ^[1] ; Robert R,Wilkening ^[2] ; Mark L,Greenlee ^[2] ; James M,Balkovec ^[2] ; Amy M,Flattery ^[2] ; George K,Abruzzo ^[2] ; Andrew M,Galgoci ^[2] ; Robert A,Giacobbe ^[2] ; Charles J,Gill ^[2] ; Ming Jo,Hsu ^[2] ; Paul,Liberator ^[2] ; Andrew S,Misura ^[2] ; Mary,Motyl ^[2] ; Jennifer,Nielsen Kahn ^[2] ; Maryann,Powles ^[2] ; Fred,Racine ^[2] ; Jasminka,Dragovic ^[2] ; Bahanu,Habulihaz ^[2] ; Weiming,Fan ^[3] ; Robin,Kirwan ^[3] ; Shu,Lee ^[3] ; Hao,Liu ^[3] ; Ahmed,Mamai ^[3] ; Kingsley,Nelson ^[3] ; Michael,Peel ^[3]

作者单位： Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. Electronic address: james_apgar@merck.com. ^[1] Merck Research Laboratories, Merck & Co. Inc., 2015 Galloping Hill Road, Kenilworth, NJ 07033, USA. ^[2] Scynexis Inc., PO Box 12878, Research Triangle Park, NC 27709, USA. ^[3]

关键词 Antifungal Candidiasis Enfumafungin Oral bioavailability β-1,3-Glucan synthesis inhibitor