Overexpression of hepatocyte growth factor in SBMA model mice has an additive effect on combination therapy with castration.

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第一作者： Ying,Ding

第一单位： Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan.

作者： Ying,Ding ^[1] ; Hiroaki,Adachi ^[2] ; Masahisa,Katsuno ^[1] ; Zhe,Huang ^[3] ; Yue-Mei,Jiang ^[1] ; Naohide,Kondo ^[1] ; Madoka,Iida ^[1] ; Genki,Tohnai ^[1] ; Hideaki,Nakatsuji ^[1] ; Hiroshi,Funakoshi ^[4] ; Toshikazu,Nakamura ^[5] ; Gen,Sobue ^[6]

作者单位： Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. ^[1] Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Department of Neurology, University of Occupational and Environmental Health School of Medicine, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Japan. Electronic address: hadachi-ns@umin.org. ^[2] Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Department of Neurology, University of Occupational and Environmental Health School of Medicine, 1-1 Iseigaoka, Yahata-nishi-ku, Kitakyushu 807-8555, Japan. ^[3] Center for Advanced Research and Education, Asahikawa Medical University, 1-1-1- Higashinijo Midorigaoka, Asahikawa 078-8510, Japan. ^[4] Neurogen Inc., 1-1-52-201 Nakahozumi, Ibaraki 567-0034, Japan. ^[5] Department of Neurology, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan; Research Division of Dementia and Neurodegenerative Disease, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya 466-8550, Japan. Electronic address: sobueg@med.nagoya-u.ac.jp. ^[6]

关键词 Akt Androgen receptor Castration Combination therapy Hepatocyte growth factor Spinal and bulbar muscular atrophy