Structure of the Dioxygenase AsqJ: Mechanistic Insights into a One-Pot Multistep Quinolone Antibiotic Biosynthesis.

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第一作者： Alois,Bräuer

第一单位： Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching (Germany).

作者： Alois,Bräuer ^[1] ; Philipp,Beck ^[1] ; Lukas,Hintermann ^[2] ; Michael,Groll ^[3]

作者单位： Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching (Germany). ^[1] Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching (Germany). lukas.hintermann@tum.de. ^[2] Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstraße 4, 85748 Garching (Germany). michael.groll@tum.de. ^[3]

关键词 4′-methoxyviridicatin AsqJ dioxygenase C?H activation alkaloids biosynthesis

主题词抗菌药(Anti-Bacterial Agents);双加氧酶类(Dioxygenases);模型, 分子(Models, Molecular);分子结构(Molecular Structure);喹诺酮类(Quinolones)

DOI 10.1002/anie.201507835

PMID 26553478

发布时间 2016-01-15

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