Pre-emptive Quality Control Protects the ER from Protein Overload via the Proximity of ERAD Components and SRP.

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第一作者： Hisae,Kadowaki

第一单位： Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan.

作者： Hisae,Kadowaki ^[1] ; Atsushi,Nagai ^[2] ; Takeshi,Maruyama ^[3] ; Yasunari,Takami ^[4] ; Pasjan,Satrimafitrah ^[4] ; Hironori,Kato ^[4] ; Arata,Honda ^[5] ; Tomohisa,Hatta ^[6] ; Tohru,Natsume ^[6] ; Takashi,Sato ^[7] ; Hirofumi,Kai ^[7] ; Hidenori,Ichijo ^[8] ; Hideki,Nishitoh ^[9]

作者单位： Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. ^[1] Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. ^[2] Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. ^[3] Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. ^[4] Organization for Promotion of Tenure Track, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan. ^[5] Biological Systems Control Team, Biomedicinal Information Research Center, National Institutes of Advanced Industrial Science and Technology, 2-42 Aomi, Koto-ku, Tokyo 135-0064, Japan. ^[6] Department of Molecular Medicine, Graduate School of Pharmaceutical Sciences, Kumamoto University, 5-1 Oe-honmachi, Kumamoto 862-0973, Japan. ^[7] Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. ^[8] Laboratory of Biochemistry and Molecular Biology, Department of Medical Sciences, University of Miyazaki, 5200 Kihara, Kiyotake, Miyazaki 889-1692, Japan; Laboratory of Cell Signaling, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan; Center of Excellence Program, Tokyo Medical and Dental University, Bunkyo-ku, Tokyo 113-8510, Japan. Electronic address: nishitoh@med.miyazaki-u.ac.jp. ^[9]