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Cancer-Associated SF3B1 Hotspot Mutations Induce Cryptic 3' Splice Site Selection through Use of a Different Branch Point.

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第一作者： Rachel B,Darman

第一单位： H3 Biomedicine, Inc., Cambridge, MA 02139, USA.

作者： Rachel B,Darman ^[1] ; Michael,Seiler ^[1] ; Anant A,Agrawal ^[1] ; Kian H,Lim ^[1] ; Shouyong,Peng ^[1] ; Daniel,Aird ^[1] ; Suzanna L,Bailey ^[1] ; Erica B,Bhavsar ^[2] ; Betty,Chan ^[1] ; Simona,Colla ^[3] ; Laura,Corson ^[1] ; Jacob,Feala ^[1] ; Peter,Fekkes ^[1] ; Kana,Ichikawa ^[1] ; Gregg F,Keaney ^[1] ; Linda,Lee ^[1] ; Pavan,Kumar ^[4] ; Kaiko,Kunii ^[1] ; Crystal,MacKenzie ^[4] ; Mark,Matijevic ^[4] ; Yoshiharu,Mizui ^[1] ; Khin,Myint ^[4] ; Eun Sun,Park ^[1] ; Xiaoling,Puyang ^[1] ; Anand,Selvaraj ^[1] ; Michael P,Thomas ^[1] ; Jennifer,Tsai ^[1] ; John Y,Wang ^[1] ; Markus,Warmuth ^[1] ; Hui,Yang ^[3] ; Ping,Zhu ^[1] ; Guillermo,Garcia-Manero ^[3] ; Richard R,Furman ^[2] ; Lihua,Yu ^[1] ; Peter G,Smith ^[1] ; Silvia,Buonamici ^[5]

作者单位： H3 Biomedicine, Inc., Cambridge, MA 02139, USA. ^[1] Department of Hematology/Oncology, Weill Cornell Medical College, New York, NY 10020, USA. ^[2] Department of Leukemia, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. ^[3] Eisai, Inc., Andover, MA 01810, USA. ^[4] H3 Biomedicine, Inc., Cambridge, MA 02139, USA. Electronic address: silvia_buonamici@h3biomedicine.com. ^[5]